Selected publications

    Piñeiro-Sabarís R, MacGrogan D, de la Pompa JL. Deficient GATA6-CXCR7 signaling leads to bicuspid aortic valve. Dis Model Mech (2024) 17:dmm050934
    Repisalud
    Henderson DJ, Alqahtani A, Chaudhry B, Cook A, Eley L, Houyel L, Hughes M, Keavney B, de la Pompa JL, Sled J, Spielmann N, Teboul L, Zaffran S, Mill P, Liu KJ. Beyond genomic studies of congenital heart defects through systematic modelling and phenotyping. Dis Model Mech (2024) 17:050913
    Repisalud
    Siguero-Álvarez M, Salguero-Jiménez A, Grego-Bessa J, de la Barrera J, MacGrogan D, Prados B, Sánchez-Sáez F, Piñeiro-Sabarís R, Felipe-Medina N, Torroja C, José Gómez M, Sabater-Molina M, Escribá R, Richaud-Patin I, Iglesias-García O, Sbroggio M, Callejas S, O'Regan DP, McGurk KA, Dopazo A, Giovinazzo G, Ibañez B, Monserrat L, María Pérez-Pomares J, Sánchez-Cabo F, Pendas AM, Raya A, Gimeno-Blanes JR, de la Pompa JL. A Human Hereditary Cardiomyopathy Shares a Genetic Substrate With Bicuspid Aortic Valve. Circulation (2023) 147:47-65
    Link to the full text in Repisalud
    Luna-Zurita L, Flores-Garza BG, Grivas D, Siguero-Álvarez M, de la Pompa JL. Cooperative Response to Endocardial Notch Reveals Interaction With Hippo Pathway. Circ Res (2023) 133:1022-1039
    Link to the full text in Repisalud
    Grego-Bessa J, Gómez-Apiñaniz P, Prados B, Gómez MJ, MacGrogan D, de la Pompa JL. Nrg1 Regulates Cardiomyocyte Migration and Cell Cycle in Ventricular Development Circ Res (2023) 133:927-943
    Link to the full text in Repisalud
    Tessler I, Albuisson J, Piñeiro-Sabarís R, Verstraeten A, Kamber Kaya HE, Siguero-Álvarez M, Goudot G, MacGrogan D, Luyckx I, Shpitzen S, Levin G, Kelman G, Reshef N, Mananet H, Holdcraft J, Muehlschlegel JD, Peloso GM, Oppenheim O, Cheng C, Mazzella JM, Andelfinger G, Mital S, Eriksson P, Billon C, Heydarpour M, Dietz HC, Jeunemaitre X, Leitersdorf E, Sprinzak D, Blacklow SC, Body SC, Carmi S, Loeys B, de la Pompa JL, Gilon D, Messas E, Durst R. Novel Association of the NOTCH Pathway Regulator MIB1 Gene With the Development of Bicuspid Aortic Valve. JAMA Cardiol (2023) 8:721-731
    Link to the full text in Repisalud
    Grivas D, González-Rajal Á, de la Pompa JL Midkine-a Regulates the Formation of a Fibrotic Scar During Zebrafish Heart Regeneration Front Cell Dev Biol (2021) 9:669439
    Torregrosa-Carrión R, Piñeiro-Sabarís R, Siguero-Álvarez M, Grego-Bessa J, Luna-Zurita L, Samuel Leite V, MacGrogan D, Stainier D Y R, de la Pompa JL Adhesion G protein-coupled receptor Gpr126/Adgrg6 is essential for placental development Sci Adv (2021) 7:eabj5445
    MacGrogan D, Martínez-Poveda B, Desvignes JP, Fernandez-Friera L, Gomez MJ, Gil Vilariño E, Callejas Alejano S, García-Pavía P, Solis J, Lucena J, Salgado D, Collod-Béroud G, Faure E, Théron A, Torrents J, Avierinos JF, Montes L, Dopazo A, Fuster V, Ibáñez B, Sánchez-Cabo F, Zaffran S, de la Pompa JL Identification of a peripheral blood gene signature predicting aortic valve calcification Physiol Genomics (2020) 52:563-574
    Link to the full text in Repisalud
    Travisano SI, Oliveira VL, Prados B, Grego-Bessa J, Pineiro-Sabaris R, Bou V, Gomez MJ, Sanchez-Cabo F, MacGrogan D, de la Pompa JL Coronary arterial development is regulated by a Dll4-Jag1-EphrinB2 signaling cascade eLife (2019) 8:e49977
    Link to the full text in Repisalud
    Torregrosa-Carrion R, Luna-Zurita L, Garcia-Marques F, D'Amato G, Pineiro-Sabaris R, Bonzon-Kulichenko E, Vazquez J, de la Pompa JL. NOTCH activation promotes valve formation by regulating the endocardial secretome. Mol Cell Proteomics (2019) 18:1782-95
    Link to the full text in Repisalud
    Del Monte-Nieto G, Ramialison M, Adam AAS, Wu B, Aharonov A, D'Uva G, Bourke LM, Pitulescu ME, Chen H, de la Pompa JL, Shou W, Adams RH, Harten SK, Tzahor E, Zhou B, Harvey RP. Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation. Nature (2018) 557:439-45
    MacGrogan D, Munch J, de la Pompa JL. Notch and interacting signalling pathways in cardiac development, disease, and regeneration. Nat Rev Cardiol (2018) 15:685-704
    Link to the full text in Repisalud
    Munch J, Grivas D, Gonzalez-Rajal A, Torregrosa-Carrion R, de la Pompa JL. Notch signalling restricts inflammation and serpine1 in the dynamic endocardium of the regenerating zebrafish heart. Development (2017) 144:1425-40
    D'Amato G, Luxan G, Del Monte-Nieto G, Martinez-Poveda B, Torroja C, Walter W, Bochter MS, Benedito R, Cole S, Martinez F, Hadjantonakis AK, Uemura A, Jimenez-Borreguero LJ, de la Pompa JL. Sequential Notch activation regulates ventricular chamber development. Nat Cell Biol (2016) 18:7-20
    de Luxan G, D'Amato G, MacGrogan D, de la Pompa JL. Endocardial Notch Signaling in Cardiac Development and Disease. Circ Res (2016) 118:e1-18
    MacGrogan D, D'Amato G, Travisano S, Martinez-Poveda B, de Luxan G, Del Monte-Nieto G, Papoutsi T, Sbroggio M, Bou V, Gomez-Del Arco P, Gomez MJ, Zhou B, Redondo JM, Jimenez-Borreguero LJ, de la Pompa JL. Sequential Ligand-Dependent Notch Signaling Activation Regulates Valve Primordium Formation and Morphogenesis. Circ Res (2016) 118:1480-97
    Nus M*, Martinez-Poveda B*, MacGrogan D*, Chevre R, D'Amato G, Sbroggio M, Rodriguez C, Martinez-Gonzalez J, Andres V, Hidalgo A, de la Pompa JL. (MN, BMP and DM contributed equally) Endothelial Jag1-RBPJ signalling promotes inflammatory leukocyte recruitment and atherosclerosis. Cardiovasc Res (2016) 112:568-80
    MacGrogan D, Luxan G, Driessen-Mol A, Bouten C, Baaijens F, de la Pompa JL How to Make a Heart Valve: From Embryonic Development to Bioengineering of Living Valve Substitutes Cold Spring Harb Perspect Med (2014) 4:a013912
    Luxán G, Casanova JC*, Martínez-Poveda B*, Prados B, D'Amato G, Macgrogan D, Gonzalez-Rajal A, Dobarro D, Torroja C, Martinez F, Izquierdo-García JL, Fernández-Friera L, Sabater-Molina M, Kong YY, Pizarro G, Ibañez B, Medrano C, García-Pavía P, Gimeno JR, Monserrat L, Jiménez-Borreguero LJ, de la Pompa JL (JCC and BMP contributed equally) Mutations in the NOTCH pathway regulator MIB1 cause left ventricular noncompaction cardiomyopathy. Nat Med (2013) 19:193-201

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