Molecular Mechanics of the Cardiovascular System

    Old news

    • May 2021. Our work examining the nanomechanics of mutant proteins that cause hypertrophic cardiomyopathy has been published in ACS Nano.
    • May 2021. In a paper in JBC we report on molecular phenotypes that identify mutations that cause hypertrophic cardiomyopathy. The paper has been selected as Editors’ Pick. Related to this work, check our commentary in Genetics in Medicine.
    • December 2022. Andra signs her Junior Leader Fellowship funded by La Caixa Foundation.
    • October 2022. Inés is awarded the EMBO Best Young Investigator Talk Prize at the EMBO Workshop on Thiol Oxidation in Biology in Sant Feliu de Guixols.
    • February 2022. Have a look at our extensive review on Hypertrophic Cardiomyopathy (HCM) and the specific role of cMyBP-C.
    • August 2021. Jorge’s review on protein nanomechanics is out in Biophysical Reviews following his designation as the recipient of the 2021 Michèle Auger Award.
    • June 2021. We review the state of the art of protein hydrogels an their mechanical properties in our latest publication.
    • February 2021. We have published the main outcome of our ERA-CVD Minotaur consortium: a potential new treatment for heart failure. Check out the paper here.
    • February 2021: Inés has been selected as a winner of the Student Research Achievement Award at the 65th Biophysical Society Meeting. She presented her work on the structure of a titin domain involved in dilated cardiomyopathy.
    • April 2020. We report a method to examine and interfere with nanomechanical properties of native proteins. Check out the paper here.
    • January 2020. We report on the functional assessment of a new variant of MYBPC3 associated to hypertrophic cardiomyopathy. Published in JCTR. Congratulations Maria Rosaria. Preprint available from here.
    • December 2019. The laboratory is recommended for promotion by CNIC’s scientific advisory board.
    • December 2019. We publish a collaborative work with Miguel Ángel del Pozo’s group on cell mechanotransduction mediated by Abl. Carla led our contribution. Paper here.
    • October 2019. The Spanish Biochemical Society (SEBBM) features Jorge in their outreach section. Publication can be accessed from here.
    • August 2019. Check out our paper on concurrent atomic force spectroscopy. Single-molecule AFM made faster and more accurate. Carolina has been awarded best Master’s Thesis for this work.
    • Summer 2019. Congratulations to David Sánchez and Inés Martínez for getting the maximum qualification for their Degree Thesis.
    • January 2019. Check out our review on the redox regulation of titin mechanics.
    • January 2019. We start the collaborative project Tec4Bio, funded by the Regional Government of Madrid and coordinated by F. Moreno-Herrero at CNB. We’ll develop new technologies to study biology and human diseases.
    • October 2018. Congratulations Carla and Ángel for your EMBO and Boehringer Travel Fellowships to visit the labs of Prof. Vunjak-Novakovic (Columbia U.) and Prof. Linke (Muenster U.)
    • September 2018. We host at CNIC the midterm meeting of MINOTAUR, a European Consortium funded by ERA-CVD to study metabolic therapies against heart failure.
    • August 2018. Jorge is awarded the element Arsenic in the periodic table of younger chemists of the IUPAC.
    • July 2018. We are part of the Spanish Network of Excellence in Mechanobiology, alongside terrific cell biologists, and theoreticians.
    • February 2018. Elías will present our latest results about titin oxidation at the Biophysical Society Meeting (San Francisco, US).
    • January 2018. Our paper describing disulfide isomerization as a new mechanism of titin elasticity is out.
    • January 2018. We welcome Ángel Fernández-Trasancos, a postdoctoral scientist who will lead generation of novel animal models to study protein mechanobiology in heart disease.
    • December 2017. We have very good news regarding our application to the Spanish Grant Program. We will get a fully funded PhD fellowship (FPI) in 2018. If interested in applying, contact Jorge.
    • October 2017. We are happy to be part of MINOTAUR, a European Consortium who will be funded by ERA-CVD to study metabolic therapies against heart failure.
    • September 2017. We will be presenting our latest results about titin oxidation at the European Muscle Conference in Potsdam, Germany.
    • July 2017. We collaborate to define the evolution of titin in the vertebrate lineage, just published in  Nature Structural and Molecular Biology.
    • June 2017: we welcome Inés Martínez and David Sánchez our cicerone students for the summer.
    • May 2017. We participate in the science fair organized by FECYT. Take a second to admire our handcrafted sarcomere designed by Natalia. Titin is definitely a molecular spring!
    • November 2016. We participated in several activities of Madrid’s Science Week. We saw fermentation in action and chromatography at local school CEIP Tagore.
    • November 2016. The VI CNIC conference “Mechanical Forces in Physiology and Disease” was a success! We have learned a good deal from world leaders in many aspects of mechanobiology. Thank you all for coming!
    • November 2016. We welcome PhD student Maria Rosaria Pricolo from Università degli Studi di Napoli "Federico II" who will spend six months with us investigating pathogenic mechanisms in cardiomyopathies.