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E.g., 27/12/2024
E.g., 27/12/2024
Marcos Siguero Álvarez, Luis Luna Zurita, José Luis de la Pompa y Brenda Giselle Flores Garza
Research
11 Dec 2023

The findings, published in the journal Circulation Research, not only highlight the gene regulatory mechanisms that control valve formation, but also offer clues for future medical advances


En primer plano: Emilio Camafeita, Rui Benedito y Macarena Fernández; detrás, de izda. a dcha., Ana Dopazo, Jesús Vázquez, Alberto Benguria, Mariya Lytvyn, Severin Muhleder, Sofía Sánchez, Lourdes García.
Research
29 May 2023

The new study, published in Nature Cardiovascular Research, will help to select the most effective and safe way to modulate angiogenesis in ischemic tissues or in cancer

Alejandro Salguero-Jiménez, Joaquim Grego-Bessa, Giovanna Giovinazzo, Fátima Sánchez-Cabo, Belén Prados, José Luis de la Pompa, Marcos Siguero-Álvarez, Sergio Callejas, Carlos Torroja, Ana Dopazo, Jorge de la Barrera, Donal MacGrogan y Manuel José Gómez.
Research
7 Nov 2022

A CNIC study reveals that mutations previously identified in the gene MINDBOMB1 (MIB1) as causing non-compaction cardiomyopathy either provoke this disease or valve defects, depending on their combination with mutations in modifier genes

Embrión de ratón con el gen Hoxb1 expresado de forma normal (izquierda) y embrión de ratón donde se expresa fuera de lugar (derecha) por la acción de Oct4
Una cámara térmica muestra el efecto de la IL-12 sobre la grasa parda en ratón.
Research
9 Jun 2022

A study published in Hepatology demonstrates that the activation of thermogenesis in the livers of obese mice contributes to weight loss and improves diabetes symptoms

Manuel José Gómez, Ester Marina-Zárate, Almudena Ramiro, Ana Dopazo, Irene Fernández-Delgado, Francisco Sánchez-Madrid y Diego Calzada-Fraile
Research
3 Feb 2021

Researchers at the CNIC have discovered that dendritic cells, which initiate specific immune responses, can reprogram their genes to improve their immune response


About the CNIC
10 Dec 2020

AngioUnrestUHD, will develop and apply new research tools and methods to advance knowledge about the biology of blood vessels in distinct physiological and pathological contexts

SRSF3 expression in adult cardiomyocytes. Pink staining shows SRSF3 expression in cell nuclei, which are stained blue. Green staining shows the presence of troponin, a sarcomere protein expressed in cardiomyocytes.
Research
4 Jul 2019

A new study published in Circulation Research shows that loss of cardiac expression of SRSF3 leads to a critical reduction in the expression of genes related to contraction

About the CNIC
6 May 2019

Image: In the picture, individual endothelial cells have different fluorescent barcodes and mitogenic stimulations, allowing the non-invasive fate-mapping of their proliferative and migratory behaviours over time.

De izda. a dcha: Almudena Ramiro, Virginia García de Yébenes, Ángel Alvarez-Prado, Carlos Torroja y Alberto Benguria.
Research
1 Feb 2018

The researchers have identified a collection of almost 300 genes mutated by AID, with some of the mutations found recurrently in human tumors and lymphomas