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    E.g., 25/08/2024
    E.g., 25/08/2024
    About the CNIC
    15 May 2024
    CNIC Co-Leads REACT, an international precision medicine project to transform cardiovascular prevention

    Globally, cardiovascular diseases due to atherosclerosis – the build-up of plaque in arteries – are the leading cause of death. A new Danish-Spanish research collaboration aims to develop methods to detect atherosclerosis at earlier ages and encourage prevention. Denmark’s Novo Nordisk Foundation has granted up to EUR 23 million to cover the first 2.5 years of the REACT initiative. The initiative is expected to run for 8 years in total
    Catarina Tristão Pereira, Enrique Lara Pezzi, Raquel Toribio Fernández, Borja Ibáñez, Valentín Fuster, Sergio Callejas, Marta Cortés Canteli, Ana Dopazo, Pilar Martín, Inés García Lunar e Irene Fernández Nueda.
    Research
    23 Jan 2024
    Circulation Research: APOE genetic variants linked to Alzheimer disease are also associated with the development of subclinical aterosclerosis

    The most potent genetic risk factor for Alzheimer disease, APOE4, is associated with an elevated risk of developing subclinical atherosclerosis in middle age, whereas the Alzheimer-protective variant of the same gene, APOE2, protects against subclinical atherosclerosis
    David Sancho
    About the CNIC
    19 Jan 2024
    The ImnovAth project, led by Dr. David Sancho, has been selected by the ERC for its Proof of Concept grants

    The ImnovAth project seeks an innovative approach to treat atherosclerosis
    Representative results from participants showing atherosclerosis progression (left) and regression (disappearance of plaques, right) in arteries of the neck (carotids) and groin (femorals). Each image pair shows the results of the initial study at baseline and the follow-up study of the same artery 6 years later. The images show representative vascular ultrasound images on the right and 3-dimensional reconstructions on the left.
    Research
    20 Nov 2023
    JACC: Younger people are more vulnerable to the effects of cardiovascular risk associated with high blood cholesterol and hypertension

    Atherosclerosis, previously believed to be an irreversible progressive disease, can be reversed if risk factors are contolled early enough
    De izda. a dcha.: Gema González, Estefanía Núñez, Sergio Callejas, Juan Carlos Silla, Enrique Lara-Pezzi, Valentín Fuster, Fátima Sánchez Cabo, José Javier Fuster, Ana Dopazo, Borja Ibáñez, Marta Cortés, Alberto Benguría y Antonio Quesada.
    Research
    21 Jun 2023
    European Heart Journal: Atherosclerosis accelerates aging

    A new CNIC study shows that low-grade systemic inflammation triggered by subcinical atherosclerosis accelerates epigenetic aging in otherwise healthy young individuals
    Enrique Calvo, Jesús Vázquez, Álvaro Alfayate, Estefanía Núñez y José Luis Martín Ventura.
    Research
    28 Mar 2022
    eBiomedicine: Spanish scientists discover a new method for the early detection of subclinical atherosclerosis

    A study published in the journal eBiomedicine identifies new biomarkers that predict the presence of subclinical atherosclerosis
    Research
    29 Jun 2021
    JACC: Spanish scientists provide the first demonstration that triglycerides are a primary risk factor in atherosclerosis

    A study published in JACC shows that excess circulating triglyceride concentrations are associated with subclinical atherosclerosis and vascular inflammation in individuals with low-to-moderate cardiovascular risk according to standard scores
    Almudena Ramiro
    About the CNIC
    15 Jun 2021
    Almudena Ramiro, Caja Rural de Granada Foundation, Health Sciences Award

    The team led by Dr Ramiro has identified a target protein for the diagnosis and treatment of vascular pathologies
    Jesús Vázquez, Jacob Fog Bentzon, Emilio Camafeita y Esmeralda Lewis.
    About the CNIC
    13 Apr 2021
    JACC: CNIC researchers explain how high blood pressure, the most important cause of disease worldwide, accelerates atherosclerosis

    The new insight supports the need to keep both LDL cholesterol and blood pressure low throughout life by healthy diet choices, weight control, exercise, and, when needed, by drug therapy
    3D reconstructions of superior (left) and inferior (right) brain regions, showing regions with lower metabolism associated with the presence of atherosclerotic plaques in the carotid arteries. The color code indicates the magnitude of the observation (yellow, strong association; red, lower association). Gray indicates areas showing no association with carotid plaque presence
    Research
    15 Feb 2021
    JACC: Spanish scientists uncover early links between cardiovascular risk and brain metabolism

    Among the modifiable cardiovascular risk factors showing a close association with reduced brain metabolism, the research team found that the most important is hypertension