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The study, published today in JACC, shows that activation of the complement system is one of the most characteristic molecular changes taking place in the early stages of the development of atherosclerotic plaques

The international team led by CNIC researchers Drs Miguel Torres and Ghislaine Lioux found that the cardiac lymphatic vasculature does not have a single origin, but is instead formed by cells originating in a variety of tissues

The project aims to study how certain mutations acquired in blood cells and traditionally associated with a high risk of developing leukemia can also contribute to the development of cardiovascular disease and become a new and independent cardiovascular risk factor to classical factors

Dra. Ivana Nikolić studies the role of T cells in the development of diseases associated with obesity

• Adiponectin, secreted by adipose tissue, protects against the development of the main form of liver cancer
• Women produce the hormone in larger quantities than men, and adiponectin release also declines in people with obesity
• The results open the route to combating a cancer for which there is currently no treatment and that is the fourth cause of death in the world.

The results, published in JACC, demonstrate the potential of this technology to generate images of the inflammation associated with systemic atherosclerosis; this information will be useful for the study of early stages of this disease and will help to identify individuals who will benefit from early medical intervention

The expression on lymphocytes of the molecule CD69 inversely predicts the development of subclinical (symptom-free) atherosclerosis independently of classical cardiovascular risk factors

The study results, published in the journal Nature Communications, identify several proteins implicated in this disease