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A team led by scientists at the CNIC and CSIC has found that accumulation of versican in the aortas of Marfan syndrome patients triggers the activation of the nitric oxide pathway through the activation of the the protein AKT

Juan Pedro Bolaños is Professor of Biochemistry and Molecular Biology at the University of Salamanca.

Dr. Carla Rothlin is Dorys McConnell Duberg Professor of Immunobiology and Professor of Pharmacology at the Yale School of Medicine, and co-leader of the Cancer Immunology Programme at Yale Cancer Centre. She studied biochemistry and pharmacology at the University of Buenos Aires, where she also undertook her postgraduate research under the direction of Dr. Ana Belén Elgoyhen, focussing on nicotinic receptors expressed in the inner ear. Later, she completed her doctorate and moved to San Diego to join Dr. Greg Lemke’s laboratory at the Salk Institute for Biological Studies. In 2009, Dr. Rothlin was named Assistant Professor in Immunobiology at Yale Medical School

The findings, published in the journal Circulation Research, not only highlight the gene regulatory mechanisms that control valve formation, but also offer clues for future medical advances

CNIC and the i+12 Institute co-lead one of the working groups of this initiative.

This work is of fundamental importance for understanding the immune system and its reactions

Neuregulin-1 (Nrg1) plays an essential role in the transformation of the heart from its delicate primordial structure into the powerful beating mature organ