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    E.g., 05/04/2025
    E.g., 05/04/2025
    Imagen de histología que muestra la comparación del tamaño del corazón de un ratón normal (izquierda) y un ratón deficiente para la proteína MKK6 (derecha).
    Research
    9 Aug 2022
    eLife: CNIC scientists uncover opposing roles of p38 proteins in cardiac hypertrophy

    A new study published in eLife shows that inhibition of p38γ/δ is a potential therapeutic strategy for the treatment of hypertrophic cardiomyopathy, but that this strategy has yet to be explored because of the lack of specific inhibitors for these p38 family members
    Participants who followed the TANSNIP-PESA program (orange line) showed an improvement in lifestyle measures and cardiovascular health compared with participants in the control group (who did not participate in the intervention; blue line). The Y-axis shows changes in the Fuster -BEWAT lifestyle and cardiovascular risk score with respect to the baseline value.
    Research
    26 Jul 2022
    European Heart Journal: “One change a day makes 365 changes in a year”

    Adherence to a workplace cardiovascular health-promotion program improves lifestyle and risk factors in healthy individuals
    Microfotografía de una monocapa de cardiomiocitos derivados de células madre inducidas a la pluripotencia, representativa de las que se usaron para estudiar los mecanismos de arritmias y el rescate de la función normal por el gen que codifica a la sintrofina-α
    Research
    29 Jun 2022
    eLife: Study reveals how Duchenne muscular dystrophy causes heart rhythm problems

    Investigadores del CNIC  revelan por primera los mecanismos moleculares que subyacen a las arritmias que ocurren en pacientes que padecen “Distrofia Muscular de Duchenne”
    Research
    17 Mar 2022
    Circulation: A CNIC study highlights the risks of mitochondrial therapeutic interventions

    The mixing of mitochondrial DNAs (mtDNAs) of two distinct origins can have damaging medium- and long-term effects, according to the results of a new study published in Circulation
    . 3D model of a femoral artery obtained by real 3D imaging, revealing the location, number, and extent of distinct atherosclerotic plaques. In this sample, three plaques can be discerned (arrows), at the femoral bifurcation and distributed along the superficial branch.
    Research
    16 Mar 2022
    JACC: 3D matrix ultrasound accurately identifies cardiovascular injury in healthy individuals

    Scientists at the CNIC have led the development of a new three dimensional ultrasound method that improves the assessment of cardiovascular risk in healthy individuals
    Daño local en las fibras musculares tras el ejercicio. Visualización del daño local en fibras de músculo esquelético (soleous y gastro) de ratón joven tras el ejercicio, mediante la tinción con marcadores de daño local como Filamina C (verde) y Evans Blue (rojo), y los núcleos (en azul) de fibras.
    Research
    18 Oct 2021
    Science: A rapid mechanism for muscle self-repair independent of stem cells

    Researchers from the National Center for Cardiovascular Research and the Pompeu Fabra University describe in Science a new mechanism for muscle regeneration after physiological damage

    Representative transmurality map from an 3D-upsampled model with a short axis view at high-magnification to illustrate the 3D methodology for transmural-based scar assessment from images obtained with conventional 2D delayed gadolinium-enhanced CMR
    Research
    28 Sep 2021
    Scientific Reports: 3D mapping of post-infarction scarring increases the prognostic potential of cardiac magnetic resonance imaging

    This innovative technology may provide an efficient approach in clinical practice after manual or automatic segmentation of myocardial borders in a small number of conventional 2D slices and automatic scar detection
    De izquierda a derecha: Enrique Lara-Pezzi, Laura Lalaguna, Laura Ramos, Elena González, María Villalba, Claudia Camarero, Marina López, Betel Olaizola, Ascensión Rey, Carlos Martí, Elísabet Bello y Javier Larrasa
    Research
    3 Sep 2021
    Circulation Research: CNIC scientists describe one of the mechanisms underlying cardiac hypertrophy

    The new findings, published in Circulation Research, could spur the development of new tools for the treatment of cardiac hypertrophy
    Research
    30 Aug 2021
    JACC: A drug costing less than €2 a day helps in the treatment of severely ill COVID-19 patients

    The safety, availability, and robust biological effect of metoprolol could together be enough to consider its use in young patients admitted to the ICU with severe COVID-19
    About the CNIC
    6 Aug 2021
    RREBOOT, on a mission to change clinical practice guidelines for the treatment of heart attack survivors

    CNIC and the Mario Negri Institute in Milan (Italy) coordinate REBOOT, a project that aims to study whether treatment with beta-blockers is beneficial for patients who have suffered a myocardial infarction