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    E.g., 23/11/2024
    E.g., 23/11/2024
    Rebeca Piñeiro-Sabarís, Marcos Siguero-Álvarez, Donald McGrogan y José Luis de la Pompa.
    Research
    5 Jul 2023
    Jama Cardiology: An international team identifies the mutations that cause the most frequent congenital heart defects

    A multicenter study published in JAMA Cardiology and co-led by scientists at Hadassah Medical Center, Sheba Medical Center, and the CNIC could help in the design of future pharmacological treatments for bicuspid aortic valve

    Dr. García Pavía
    Research
    21 May 2023
    NEJM: A Spanish team presents the first pharmacological treatment able to improve cardiac function in stiff-heart syndrome

    The team led by Dr. Pablo García-Pavía, based at the CNIC and Hospital Puerta de Hierro, has published the first study of a drug able to remove amyloid deposits from the heart

    Miguel Galán, David Sancho, Stefanie K. Wculek, Annalaura Mastrangelo, Verónica Miguel ,Ignacio Heras-Murillo, Diego Mañanes, José Antonio Enríquez and Andrea Curtabbi.
    Research
    3 Feb 2023
    IMMUNITY: Scientists identify a new therapeutic target in macrophages for the treatment of obesity-related diseases

    The discovery, published in the journal Immunity, identifies a new therapeutic route for conditions associated with obesity and metabolic syndrome, including cardiovascular disease
    La figura muestra imágenes mediante resonancia magnética cardíaca (A y B) y tomografía computarizada (C y D) de un corazón en diástole (A y C) y sístole (B y D) para el cálculo de la función de ambos ventrículos. VD: Ventrículo derecho; VI: Ventrículo izquierdo.
    Research
    12 Dec 2022
    European Journal of Heart Failure: A promising drug treatment for patients with pulmonary hypertension associated with heart disease

    The results of the SPHERE-HF study are published in the European Journal of Heart Failure. SPHERE-HF is a multicenter academic clinical trial led by investigators at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) and Hospital Clínic de Barcelona
    Pablo García Pavía and Luis Escobar
    Research
    12 Sep 2022
    JACC: Scientists at the CNIC and Hospital Puerta de Hierro develop a tool to determine if dilated cardiomyopathy has a genetic origin

    The findings, published in the Journal of the American College of Cardiology (JACC), will enable physicians to make appropriate treatment adjustments for patients with this disease
    Imagen de histología que muestra la comparación del tamaño del corazón de un ratón normal (izquierda) y un ratón deficiente para la proteína MKK6 (derecha).
    Research
    9 Aug 2022
    eLife: CNIC scientists uncover opposing roles of p38 proteins in cardiac hypertrophy

    A new study published in eLife shows that inhibition of p38γ/δ is a potential therapeutic strategy for the treatment of hypertrophic cardiomyopathy, but that this strategy has yet to be explored because of the lack of specific inhibitors for these p38 family members
    Participants who followed the TANSNIP-PESA program (orange line) showed an improvement in lifestyle measures and cardiovascular health compared with participants in the control group (who did not participate in the intervention; blue line). The Y-axis shows changes in the Fuster -BEWAT lifestyle and cardiovascular risk score with respect to the baseline value.
    Research
    26 Jul 2022
    European Heart Journal: “One change a day makes 365 changes in a year”

    Adherence to a workplace cardiovascular health-promotion program improves lifestyle and risk factors in healthy individuals
    Microfotografía de una monocapa de cardiomiocitos derivados de células madre inducidas a la pluripotencia, representativa de las que se usaron para estudiar los mecanismos de arritmias y el rescate de la función normal por el gen que codifica a la sintrofina-α
    Research
    29 Jun 2022
    eLife: Study reveals how Duchenne muscular dystrophy causes heart rhythm problems

    Investigadores del CNIC  revelan por primera los mecanismos moleculares que subyacen a las arritmias que ocurren en pacientes que padecen “Distrofia Muscular de Duchenne”
    Research
    17 Mar 2022
    Circulation: A CNIC study highlights the risks of mitochondrial therapeutic interventions

    The mixing of mitochondrial DNAs (mtDNAs) of two distinct origins can have damaging medium- and long-term effects, according to the results of a new study published in Circulation
    . 3D model of a femoral artery obtained by real 3D imaging, revealing the location, number, and extent of distinct atherosclerotic plaques. In this sample, three plaques can be discerned (arrows), at the femoral bifurcation and distributed along the superficial branch.
    Research
    16 Mar 2022
    JACC: 3D matrix ultrasound accurately identifies cardiovascular injury in healthy individuals

    Scientists at the CNIC have led the development of a new three dimensional ultrasound method that improves the assessment of cardiovascular risk in healthy individuals