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    E.g., 22/11/2024
    E.g., 22/11/2024
    Cardiovascular risk factors (particularly metabolic syndrome, insulin resistance, and diabetes) alter coronary microvascular function and increase the risk of atherosclerotic disease, which itself leads to changes in the coronary microcirculation.
    Research
    19 Sep 2024
    JACC: Cardiovascular Imaging: Cardiometabolic risk factors in apparently healthy individuals are linked to altered coronary microcirculation

    A study from CNIC reveals how risk factors and subclinical atherosclerosis affect heart microcirculation in asymptomatic middle-aged individuals. The research, published in JACC: Cardiovascular Imaging, highlights the importance of assessing the heart vessels' ability to regulate blood flow and predict future cardiovascular risk
    CNIC researchers
    Research
    30 Aug 2024
    Nature Medicine: CNIC scientists discover a new cardiovascular risk factor and identify a drug able to reduce its effects

    Two studies carried out at the CNIC provide key information about a newly identified cardiovascular risk factor, clonal hematopoiesis, and its treatment with the ancient medication colchicine
    Carlos Torroja, Jacob F. Bentzon, Paula Nogales, Laura Carramolino, Vanessa Cumbicus, Daniel Morales, Ana Dopazo, Verónica Labrador y Alberto Benguria
    Research
    1 Feb 2024
    Nature Cardiovascular Research: New approach to the design of therapies that enhance the effect of cholesterol-lowering drugs

    A study published in Nature Cardiovascular Research reveals smooth muscle-derived cells as a new target for reducing the size of atherosclerotic plaque. The results open up new avenues for the design of treatments to enhance the beneficial effect of cholesterol-lowering drugs
    Representative results from participants showing atherosclerosis progression (left) and regression (disappearance of plaques, right) in arteries of the neck (carotids) and groin (femorals). Each image pair shows the results of the initial study at baseline and the follow-up study of the same artery 6 years later. The images show representative vascular ultrasound images on the right and 3-dimensional reconstructions on the left.
    Research
    20 Nov 2023
    JACC: Younger people are more vulnerable to the effects of cardiovascular risk associated with high blood cholesterol and hypertension

    Atherosclerosis, previously believed to be an irreversible progressive disease, can be reversed if risk factors are contolled early enough
    De izquierda a derecha: Cristina Sanchez-Ramos, Nieves Garcia-Quintans, David Morera, Mariya Lytvyn, Juan A Bernal, Mª Ángeles Sanguino, Daniel Martín Perez, Fernando de Benito, David Sanz y Emilio Camafeita
    Research
    23 Oct 2023
    Nature Communications: Spanish scientists discover a possible treatment for a heart condition that causes an estimated 20% of sudden deaths among athletes

    This disease, which can trigger sudden death in elite athletes, is caused by genetic mutations that affect proteins responsible for connecting and coordinating the muscle cells (myocytes) in the myocardium the heart’s muscular wall
    About the CNIC
    3 Oct 2023
    CNIC gets on the move with the Carrera del Corazón fun run
    About the CNIC
    4 Aug 2023
    A new technique offers improved diagnostic precision and a route to personalized therapy for a common arrhythmia that affects more than 10 million people in Europe
    Rebeca Piñeiro-Sabarís, Marcos Siguero-Álvarez, Donald McGrogan y José Luis de la Pompa.
    Research
    5 Jul 2023
    Jama Cardiology: An international team identifies the mutations that cause the most frequent congenital heart defects

    A multicenter study published in JAMA Cardiology and co-led by scientists at Hadassah Medical Center, Sheba Medical Center, and the CNIC could help in the design of future pharmacological treatments for bicuspid aortic valve

    En primer plano: Emilio Camafeita, Rui Benedito y Macarena Fernández; detrás, de izda. a dcha., Ana Dopazo, Jesús Vázquez, Alberto Benguria, Mariya Lytvyn, Severin Muhleder, Sofía Sánchez, Lourdes García.
    Research
    29 May 2023
    Nature Cardiovascular Research: Scientists identify how some angiogenic drugs used to treat cancer and heart disease cause vascular disease

    The new study, published in Nature Cardiovascular Research, will help to select the most effective and safe way to modulate angiogenesis in ischemic tissues or in cancer
    Alejandro Salguero-Jiménez, Joaquim Grego-Bessa, Giovanna Giovinazzo, Fátima Sánchez-Cabo, Belén Prados, José Luis de la Pompa, Marcos Siguero-Álvarez, Sergio Callejas, Carlos Torroja, Ana Dopazo, Jorge de la Barrera, Donal MacGrogan y Manuel José Gómez.
    Research
    7 Nov 2022
    Circulation: Specific modifier genes determine the effect of mutations that cause non-compaction cardiomyopathy

    A CNIC study reveals that mutations previously identified in the gene MINDBOMB1 (MIB1) as causing non-compaction cardiomyopathy either provoke this disease or valve defects, depending on their combination with mutations in modifier genes