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    E.g., 22/11/2024
    E.g., 22/11/2024
    Carlos Torroja, Jacob F. Bentzon, Paula Nogales, Laura Carramolino, Vanessa Cumbicus, Daniel Morales, Ana Dopazo, Verónica Labrador y Alberto Benguria
    Research
    1 Feb 2024
    Nature Cardiovascular Research: New approach to the design of therapies that enhance the effect of cholesterol-lowering drugs

    A study published in Nature Cardiovascular Research reveals smooth muscle-derived cells as a new target for reducing the size of atherosclerotic plaque. The results open up new avenues for the design of treatments to enhance the beneficial effect of cholesterol-lowering drugs
    Representative results from participants showing atherosclerosis progression (left) and regression (disappearance of plaques, right) in arteries of the neck (carotids) and groin (femorals). Each image pair shows the results of the initial study at baseline and the follow-up study of the same artery 6 years later. The images show representative vascular ultrasound images on the right and 3-dimensional reconstructions on the left.
    Research
    20 Nov 2023
    JACC: Younger people are more vulnerable to the effects of cardiovascular risk associated with high blood cholesterol and hypertension

    Atherosclerosis, previously believed to be an irreversible progressive disease, can be reversed if risk factors are contolled early enough
    Jesús Vázquez, Jacob Fog Bentzon, Emilio Camafeita y Esmeralda Lewis.
    About the CNIC
    13 Apr 2021
    JACC: CNIC researchers explain how high blood pressure, the most important cause of disease worldwide, accelerates atherosclerosis

    The new insight supports the need to keep both LDL cholesterol and blood pressure low throughout life by healthy diet choices, weight control, exercise, and, when needed, by drug therapy
    A cholesterol plaque in a carotid artery, visualized by vascular magnetic resonance imaging.
    Research
    12 Dec 2017
    'JACC': LDL cholesterol is the main modifiable predictor of atherosclerosis in individuals with no risk factors

    CNIC researchers have demonstrated that, after age and male sex, LDL-C is the main predictor of the presence of arterial atherosclerotic plaques
    3D ultrasound of the right carotid artery. An atherosclerotic plaque is visible as a small protrusion (arrow) in the vessel wall of the internal branch of the proximal carotid artery (bottom), close to the bifurcation. In contrast, the surface of the disease-free external branch (top) is smooth (asterisk).
    Research
    24 Jul 2017
    'JACC': 3D visualization of cholesterol plaques improves cardiovascular risk prediction

    CNIC researchers show the value of total atherosclerosis burden for the identification of individuals at risk of cardiovascular disease
    Ignacio Flores, Juan M. Fernández-Alvira, Valentín Fuster, Vicente Andrés y Beatriz Dorado
    Research
    24 May 2016
    JACC: Telomere length in circulating blood cells does not predict asymptomatic atherosclerosis

    Half of patients with CVD show no above-normal risk of developing the disease on the basis of classical risk factors, such as high cholesterol, smoking, lack of exercise, and high blood pressure