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    E.g., 26/12/2024
    E.g., 26/12/2024
    Back row: Víctor Jiménez, Mónica Toledano, Miguel Ángel del Pozo Barriuso, María Aboy Pardal, Sara Terrés, Daniel Jiménez, Fidel Lolo. Front row: Miguel Sánchez, Mauro Catalá, Asier Echarri.
    Research
    28 Nov 2024
    CNIC scientists discover a key mechanism in fat cells that protects the body against energetic excess

    A study from the CNIC, published in Nature Communications, reveals how caveolae allow adipocytes to expand safely, storing fat without breaking or causing inflammation
    Cells use two mechanisms to detect force: one gradual and progressive mediated by newly identified large membrane depressions called dolines (left); the other abrupt, activated above a certain threshold, and mediated by minute membrane invaginations called caveolae (right).
    Research
    23 Dec 2022
    Nature Cell Biology: A CNIC study shows that cells possess 2 mechanisms to allow them to respond to different force ranges

    A study published in Nature Cell Biology confirms that caveolae are essential for the mechanical responses of tissues subject to large mechanical forces (such as muscle, heart, blood vessels, and fat), whereas larger membrane depressions (termed 'dolines') are important for the response to weak or medium-strength forces
    Fibroblasto embrionario murino Cav1KO (izquierda, sin caveolas) muestra un mayor reclutamiento de integrina beta 1 activa (magenta) en torno a bolitas recubiertas con fibronectina, en comparación con un fibroblasto embrionario murino Cav1WT (derecha, con caveolas).
    Research
    13 Dec 2022
    eLife:CNIC scientists identify the essential role of cell-surface "nanofolds" and "glue" in the mechanical response of cells

    A new study published in eLife shows that small cups or nanofolds on the cell membrane called caveolae, by limiting abrupt changes in membrane tension, regulate the number and activity of mechanical microsensors on the cell surface called integrins