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    E.g., 15/04/2025
    E.g., 15/04/2025
    Cells use two mechanisms to detect force: one gradual and progressive mediated by newly identified large membrane depressions called dolines (left); the other abrupt, activated above a certain threshold, and mediated by minute membrane invaginations called caveolae (right).
    Research
    23 Dec 2022
    Nature Cell Biology: A CNIC study shows that cells possess 2 mechanisms to allow them to respond to different force ranges

    A study published in Nature Cell Biology confirms that caveolae are essential for the mechanical responses of tissues subject to large mechanical forces (such as muscle, heart, blood vessels, and fat), whereas larger membrane depressions (termed 'dolines') are important for the response to weak or medium-strength forces
    Cellular and Molecular Sciences: Describen un nuevo mecanismo que relaciona la inflamación y el remodelado cardiovascular patológico
    Research
    29 Sep 2022
    Cellular and Molecular Sciences: Describing a new mechanism that links inflammation and pathological cardiovascular remodelling
    Microfotografía de una monocapa de cardiomiocitos derivados de células madre inducidas a la pluripotencia, representativa de las que se usaron para estudiar los mecanismos de arritmias y el rescate de la función normal por el gen que codifica a la sintrofina-α
    Research
    29 Jun 2022
    eLife: Study reveals how Duchenne muscular dystrophy causes heart rhythm problems

    Investigadores del CNIC  revelan por primera los mecanismos moleculares que subyacen a las arritmias que ocurren en pacientes que padecen “Distrofia Muscular de Duchenne”
    An optical section from a ventral view of a mouse embryo at embryonic day E8.0. The section is overlain with a cast of the three-dimensional shape of the forming heart (red) and the incipient circulatory system (purple).
    Research
    17 May 2022
    Nature Cardiovascular Research: A CNIC team creates a dynamic 3D atlas of the formation of the embryonic heart

    The 3D atlas has allowed the scientists to identify the beginning of left–right asymmetry in the heart
    Dr. Cristóbal Belda se convirtió en el nuevo Director del Instituto de Salud Carlos III.
    Research
    11 May 2022
    Cristóbal Belda, Director del ISCIII: “PERTE represents an opportunity to help our country”
    Miguel Palomino Segura, Georgiana Crainiciuc, Jon Sicilia y Andrés Hidalgo
    Research
    5 Jan 2022
    Nature: CNIC scientists discover a cell behavior pattern that predicts cardiovascular disease

    Scientists at the CNIC have developed a simple model for studying the behavior of immune cells in live animals and have identified a harmful cell behavior pattern associated with cardiovascular disease
    Álvaro Macías, Jesús Vázquez, Pilar Gonzalo, Carla Espinós, Beatriz Dorado, Emilio Camafeita, Vicente Andrés, María J Andrés, Cristina González, Amanda Sánchez, Víctor Fanjul.
    Research
    26 Oct 2021
    CIRCULATION: It's never too late to treat progeria

    Scientists from the CNIC and the CIBERCV have generated the first experimental animal model that develops Hutchinson-Gilford Progeria Syndrome and allows its controlled reversal
    About the CNIC
    6 Aug 2021
    RREBOOT, on a mission to change clinical practice guidelines for the treatment of heart attack survivors

    CNIC and the Mario Negri Institute in Milan (Italy) coordinate REBOOT, a project that aims to study whether treatment with beta-blockers is beneficial for patients who have suffered a myocardial infarction

    Dra. Sabio
    About the CNIC
    17 Jun 2021
    Dr Guadalupe Sabio awarded the Banco Sabadell Foundation Prize for Biomedical Research

    The jury acknowledged this CNIC researcher's contribution to understanding why obesity causes cardiometabolic diseases.
    About the CNIC
    8 Jun 2021
    José Antonio Enríquez and Miguel Ángel del Pozo, new members of EMBO

    Dr Enríquez and Dr del Pozo Muñoz join their colleagues Dr Miguel Torres, Dr Pura Muñoz and Dr Francisco Sánchez Madrid,  bringing to five the number of CNIC members in EMBO