Publicaciones seleccionadas

    Martinez-Martin I, Crousilles A, Ochoa JP, Velazquez-Carreras D, Mortensen SA, Herrero-Galan E, Delgado J, Dominguez F, Garcia-Pavia P, de Sancho D, Wilmanns M, Alegre-Cebollada J. Titin domains with reduced core hydrophobicity cause dilated cardiomyopathy. Cell Rep (2023) Nov 23 [Epub ahead of print]
    Link to the full text in Repisalud
    Herrero-Galán, E., Martínez-Martín, I., Sánchez-González, C., Vicente, N., Bonzón-Kulichenko, E., Calvo, E., Suay-Corredera, C., Pricolo, M. R., Fernández-Trasancos, Á., Velázquez-Carreras, D., Careaga, C. B., Abdellatif, M., Sedej, S., Rainer, P. P., Giganti, D., Pérez-Jiménez, R., Vázquez, J., & Alegre-Cebollada, J. Basal oxidation of conserved cysteines modulates cardiac titin stiffness and dynamics Redox Biol (2022) 52
    Link to the full text in Repisalud
    Suay-Corredera C, Alegre-Cebollada J. The mechanics of the heart: zooming in on hypertrophic cardiomyopathy and cMyBP-C. FEBS Lett (2022) 596:703-746
    Link to the full text in Repisalud
    Suay-Corredera C, Pricolo MR, Velázquez-Carreras D, Pathak D, Nandwani N, Pimenta-Lopes C, Sánchez-Ortiz D, Urrutia-Irazabal I, Vilches S, Dominguez F, Frisso G, Monserrat L, García-Pavía P, de Sancho D, Spudich JA, Ruppel KM, Herrero-Galán E, Alegre-Cebollada J Nanomechanical Phenotypes in Cardiac Myosin-Binding Protein C Mutants That Cause Hypertrophic Cardiomyopathy ACS NANO (2021) Jun 2 [Epub ahead of print]
    Link to the full text in Repisalud
    Suay-Corredera C, Alegre-Cebollada J Correspondence on "Computational prediction of protein subdomain stability in MYBPC3 enables clinical risk stratification in hypertrophic cardiomyopathy and enhances variant interpretation" by Thompson et al GENET MED (2021) Jun 12 [Epub ahead of print]
    Suay-Corredera C, Pricolo MR, Herrero-Galán E, Velázquez-Carreras D, Sánchez-Ortiz D, García-Giustiniani D, Delgado J, Galano-Frutos JJ, García-Cebollada H, Vilches S, Domínguez F, Molina MS, Barriales-Villa R, Frisso G, Sancho J, Serrano L, García-Pavía P, Monserrat L, Alegre-Cebollada J Protein haploinsufficiency drivers identify MYBPC3 variants that cause hypertrophic cardiomyopathy J Biol Chem (2021) :100854
    Abdellatif M, Trummer-Herbst V, Koser F, Durand S, Adão R, Vasques-Nóvoa F, Freundt JK, Voglhuber J, Pricolo MR, Kasa M, Türk C, Aprahamian F, Herrero-Galán E, Hofer SJ, Pendl T, Rech L, Kargl J, Anto-Michel N, Ljubojevic-Holzer S, Schipke J, Brandenberger C, Auer M, Schreiber R, Koyani CN, Heinemann A, Zirlik A, Schmidt A, von Lewinski D, Scherr D, Rainer PP, von Maltzahn J, Mühlfeld C, Krüger M, Frank S, Madeo F, Eisenberg T, Prokesch A, Leite-Moreira AF, Lourenço AP, Alegre-Cebollada J, Kiechl S, Linke WA, Kroemer G, Sedej S Nicotinamide for the treatment of heart failure with preserved ejection fraction Sci Transl Med (2021) 13
    Enlace al texto en Pubmed Central
    Alegre-Cebollada J Protein nanomechanics in biological context Biophys Rev (2021) 13:435–454
    Link to the journal
    Nicolas-Avila JA, Lechuga-Vieco AV, Esteban-Martinez L, Sanchez-Diaz M, Diaz-Garcia E, Santiago DJ, Rubio-Ponce A, Li JL, Balachander A, Quintana JA, Martinez-de-Mena R, Castejon-Vega B, Pun-Garcia A, Traves PG, Bonzon-Kulichenko E, Garcia-Marques F, Cusso L, N AG, Gonzalez-Guerra A, Roche-Molina M, Martin-Salamanca S, Crainiciuc G, Guzman G, Larrazabal J, Herrero-Galan E, Alegre-Cebollada J, Lemke G, Rothlin CV, Jimenez-Borreguero LJ, Reyes G, Castrillo A, Desco M, Munoz-Canoves P, Ibanez B, Torres M, Ng LG, Priori SG, Bueno H, Vazquez J, Cordero MD, Bernal JA, Enriquez JA, Hidalgo A A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart Cell (2020) 183:94-109
    Link to the full text in Repisalud
    Rivas-Pardo JA, Li Y, Mártonfalvi Z, Tapia-Rojo R, Unger A, Fernández-Trasancos Á, Herrero-Galán E, Velázquez-Carreras D, Fernández JM, Linke WA, Alegre-Cebollada J A HaloTag-TEV genetic cassette for mechanical phenotyping of proteins from tissues Nat Commun (2020) 11:2060
    Link to the full text in Repisalud
    Pricolo MR*, Herrero-Galan E, Mazzaccara C, Losi MA, Alegre-Cebollada J*, Frisso G *(MRP and JAC are both co-corresponding authors) Protein Thermodynamic Destabilization in the Assessment of Pathogenicity of a Variant of Uncertain Significance in Cardiac Myosin Binding Protein C J Cardiovasc Transl Res (2020) 13:867-877
    Link to the full text in Repisalud
    Echarri A, Pavon DM, Sanchez S, Garcia-Garcia M, Calvo E, Huerta-Lopez C, Velazquez-Carreras D, Viaris de Lesegno C, Ariotti N, Lazaro-Carrillo A, Strippoli R, De Sancho D, Alegre-Cebollada J, Lamaze C, Parton RG, Del Pozo MA An Abl-FBP17 mechanosensing system couples local plasma membrane curvature and stress fiber remodeling during mechanoadaptation Nat Commun (2019) 10:5828
    Link to the full text in Repisalud
    Herrero-Galan E, Martinez-Martin I, Alegre-Cebollada J. Redox regulation of protein nanomechanics in health and disease: lessons from titin. Redox Biol (2019) 21:101074
    Link to the full text in Repisalud
    Pimenta-Lopes C, Suay-Corredera C, Velázquez-Carreras D, Sánchez-Ortiz D, Alegre-Cebollada J. Concurrent atomic force spectroscopy. Comms Phys (2019) 2:91
    Link to the full text in Repisalud
    Giganti D, Yan K, Badilla CL, Fernandez JM, Alegre-Cebollada J. Disulfide isomerization reactions in titin immunoglobulin domains enable a mode of protein elasticity. Nat Commun (2018) 9:185
    Link to the full text in Repisalud
    Manteca A, Schonfelder J, Alonso-Caballero A, Fertin MJ, Barruetabena N, Faria BF, Herrero-Galan E, Alegre-Cebollada J, De Sancho D, Perez-Jimenez R. Mechanochemical evolution of the giant muscle protein titin as inferred from resurrected proteins. Nat Struct Mol Biol (2017) 24:652-7
    Link to the full text in Repisalud
    Echelman DJ, Alegre-Cebollada J, Badilla CL, Chang C, Ton-That H, Fernandez JM. CnaA domains in bacterial pili are efficient dissipaters of large mechanical shocks. Proc Natl Acad Sci U S A (2016) 113:2490-5
    Alegre-Cebollada J, Kosuri P, Giganti D, Eckels E, Rivas-Pardo JA, Hamdani N, Warren CM, Solaro RJ, Linke WA, Fernández JM S-glutathionylation of cryptic cysteines enhances titin elasticity by blocking protein folding Cell (2014) 156:1234-46
    Kosuri P, Alegre-Cebollada J, Feng J, Kaplan A, Inglés-Prieto A, Badilla CL, Stockwell BR, Sanchez-Ruiz JM, Holmgren A, Fernández JM Protein folding drives disulfide formation Cell (2012) 151:794-806
    Alegre-Cebollada J, Kosuri P, Rivas-Pardo JA, Fernández JM. Direct observation of disulfide isomerization in a single protein. Nat Chem (2011) 3:882-7

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