Movie 1. 3D reconstruction of E9.5 wild type heart. Red, myocardium. Grey, endocardium
Movie 2. 3D reconstruction of E9.5 Nrg1 mutant heart. Red, myocardium. Grey, endocardium
3D AVC explant of E9.5 WT embryo. GFP expression of mTmG transgenic mice upon VECadherinCREERT2 activation
using a low dosage pulse of Tamoxifen. GFP is expressed only in a small number of endocardial cells.
Confocal Time Lapse movies showed transformed cells in green building cellular projections toward collagen matrix.
2D ventricular explant of WT E9.5 embryo. GFP expression of mTmG transgenic mice upon VECadherinCREERT2
activation using a low dosage pulse of Tamoxifen. GFP is expressed only in a small number of endocardial cells.
Confocal Time Lapsemovies showed single endocardial cells forming lamellipodia in the growth
front, and cells forming filopodia when surrounded by other endocardial cells.
3D reconstruction of an E10.5 mouse heart stained with SMA, IB4 and DAPI to show the complex structure of the trabeculated ventricle.
Lab in December 2024. From left to right: D. MacGrogan, B. Flores-Garza, T. González-Costa,
V. Sebastián-Serrano, J.L. de la Pompa, L. Méndez-Peralta, A. Pau-Navalón, A. Galicia-Martín,
J. Santos-Cantador, C. Relaño-Ruperez, M. Siguero-Álvarez.
Lab in January 2024. From left to right: D. MacGrogan, B. Flores-Garza, T. González-Costa,
V. Sebastián-Serrano, J.L. de la Pompa, L. Méndez-Peralta, A. Pau-Navalón, A. Galicia-Martín,
J. Santos-Cantador, C. Relaño-Ruperez, M. Siguero-Álvarez.
Lab in 2022. Back row, left to right: J. Grego-Bessa, MacGrogan, M. Siguero-Álvarez,
C. Relaño-Ruperez, V. Sebastián-Serrano, A. Galicia-Martín, A. Pau-Navalón, R. Piñeiro-Chavarís,
B. Flores-Garza, L. Méndez-Peralta, T. González-Costa, J.L. de la Pompa.
José Luis giving a talk at the Institute of Developmental Biology in Marseille (IDBM).
Lab in 2021
Lab in 2016
Lab in 2013
Lab in 2010
