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    E.g., 22/11/2024
    E.g., 22/11/2024
    Imagen de histología que muestra la comparación del tamaño del corazón de un ratón normal (izquierda) y un ratón deficiente para la proteína MKK6 (derecha).
    Research
    9 Aug 2022
    eLife: CNIC scientists uncover opposing roles of p38 proteins in cardiac hypertrophy

    A new study published in eLife shows that inhibition of p38γ/δ is a potential therapeutic strategy for the treatment of hypertrophic cardiomyopathy, but that this strategy has yet to be explored because of the lack of specific inhibitors for these p38 family members
    An optical section from a ventral view of a mouse embryo at embryonic day E8.0. The section is overlain with a cast of the three-dimensional shape of the forming heart (red) and the incipient circulatory system (purple).
    Research
    17 May 2022
    Nature Cardiovascular Research: A CNIC team creates a dynamic 3D atlas of the formation of the embryonic heart

    The 3D atlas has allowed the scientists to identify the beginning of left–right asymmetry in the heart
    Alfonso Mora, Ayelén Santamans, Luis Leiva, Guadalupe Sabio, José Antonio Enríquez y Barbara Gonzalez Terán.
    Research
    24 Nov 2021
    PLoS Biology: CNIC scientists identify two proteins essential for postnatal cardiac metabolism

    The study, published in PLoS Biology, shows for the first time that cardiac metabolism in the postnatal period determines the regulation of metabolism in the whole body
    Daño local en las fibras musculares tras el ejercicio. Visualización del daño local en fibras de músculo esquelético (soleous y gastro) de ratón joven tras el ejercicio, mediante la tinción con marcadores de daño local como Filamina C (verde) y Evans Blue (rojo), y los núcleos (en azul) de fibras.
    Research
    18 Oct 2021
    Science: A rapid mechanism for muscle self-repair independent of stem cells

    Researchers from the National Center for Cardiovascular Research and the Pompeu Fabra University describe in Science a new mechanism for muscle regeneration after physiological damage

    Representative transmurality map from an 3D-upsampled model with a short axis view at high-magnification to illustrate the 3D methodology for transmural-based scar assessment from images obtained with conventional 2D delayed gadolinium-enhanced CMR
    Research
    28 Sep 2021
    Scientific Reports: 3D mapping of post-infarction scarring increases the prognostic potential of cardiac magnetic resonance imaging

    This innovative technology may provide an efficient approach in clinical practice after manual or automatic segmentation of myocardial borders in a small number of conventional 2D slices and automatic scar detection
    De izquierda a derecha: Enrique Lara-Pezzi, Laura Lalaguna, Laura Ramos, Elena González, María Villalba, Claudia Camarero, Marina López, Betel Olaizola, Ascensión Rey, Carlos Martí, Elísabet Bello y Javier Larrasa
    Research
    3 Sep 2021
    Circulation Research: CNIC scientists describe one of the mechanisms underlying cardiac hypertrophy

    The new findings, published in Circulation Research, could spur the development of new tools for the treatment of cardiac hypertrophy
    Dr. Miguel Torres
    About the CNIC
    10 May 2021
    Dr. Miguel Torres appointed Associate Editor of Science Advances

    Dr. Torres is a member of the European Molecular Biology Organization (EMBO). Dr. Miguel Torres’s scientific research focuses on the regulation of embryonic development and the formation and regeneration of organs.

    3D images obtained in anatomical, functional, and tissue characterization studies performed with the ultrafast cardiac magnetic resonance protocol
    Research
    22 Apr 2021
    JACC: CNIC and Philips develop ultrafast cardiac magnetic resonance technology that analyzes the heart in less than 1 minute

    Ultrafast cardiac magnetic resonance allows precise assessment of heart anatomy and function while reducing healthcare costs and increasing patient comfort
    Mª Ángeles Zuriaga, Mirian Díez, Fátima Sánchez-Cabo, Ana Dopazo, José Javier Fuster, Ana Quintas y Jorge de la Barrera.
    Research
    5 Apr 2021
    JACC: CNIC scientists identify mutations acquired by blood cells that accelerate heart failure progression

    The study, carried out at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) and the Hospital Universitario Virgen de Arrixaca in Murcia, establishes clonal hematopoiesis as a new cardiovascular risk factor and an important link between aging and cardiovascular disease
    Research
    27 Oct 2020
    Nature Cell Biology: Researchers identify a subgroup of stem cells that resists ageing and maintains muscle regeneration capacity until geriatric age

    The finding provides a basis for mitigating the loss of muscle regenerative capacity in very elderly people.