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    E.g., 25/11/2024
    E.g., 25/11/2024
    Las células senescentes (mostradas por luminiscencia) aparecieron en el hombro de ratón después de la lesión
    Research
    19 Dec 2022
    Nature: Researchers characterize rare, damaged cells that block the functions of their neighbour healthy cells and identify ways to neutralize them and improve tissue regeneration

    The finding provides a basis for mitigating the loss of muscle regenerative capacity in elderly people and for improving muscle repair in young healthy people
    Mercedes Ricote, María Piedad Menéndez-Gutiérrez, Jesús Porcuna, Ana Paredes, Vanessa Núñez e Irene Calero.
    Research
    15 Dec 2022
    Blood: RXR, the cell protein that keeps blood stem cells young and fit

    A CNIC team has shown that the  retinoid and unsaturated fatty acid sensor RXR is a key protein in the maintenance of a balanced production of the different types of blood cells
    Fibroblasto embrionario murino Cav1KO (izquierda, sin caveolas) muestra un mayor reclutamiento de integrina beta 1 activa (magenta) en torno a bolitas recubiertas con fibronectina, en comparación con un fibroblasto embrionario murino Cav1WT (derecha, con caveolas).
    Research
    13 Dec 2022
    eLife:CNIC scientists identify the essential role of cell-surface "nanofolds" and "glue" in the mechanical response of cells

    A new study published in eLife shows that small cups or nanofolds on the cell membrane called caveolae, by limiting abrupt changes in membrane tension, regulate the number and activity of mechanical microsensors on the cell surface called integrins
    La figura muestra imágenes mediante resonancia magnética cardíaca (A y B) y tomografía computarizada (C y D) de un corazón en diástole (A y C) y sístole (B y D) para el cálculo de la función de ambos ventrículos. VD: Ventrículo derecho; VI: Ventrículo izquierdo.
    Research
    12 Dec 2022
    European Journal of Heart Failure: A promising drug treatment for patients with pulmonary hypertension associated with heart disease

    The results of the SPHERE-HF study are published in the European Journal of Heart Failure. SPHERE-HF is a multicenter academic clinical trial led by investigators at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) and Hospital Clínic de Barcelona
    Transverse heart sections from wild type mice (WT) and transgenic mice overexpressing beta-3 adrenergic receptor in cardiomyocytes (c-h3tg) after 3 months of aortic stenosis (transaortic constriction, TAC) or control (sham). Hypertrophy after TAC was less severe in the transgenic mice
    Research
    29 Nov 2022
    Basic Research in Cardiology: A new therapeutic target for the prevention of heart failure due to aortic stenosis

    The experimental study, led by researchers at the CNIC, shows that boosting the expression of this adrenalin receptor in heart cells improves mitochondrial function in the heart
    About the CNIC
    23 Nov 2022
    The Francisco Cobos Foundation Grants the 16th scientific career award o José Antonio Enríquez
    Alejandro Salguero-Jiménez, Joaquim Grego-Bessa, Giovanna Giovinazzo, Fátima Sánchez-Cabo, Belén Prados, José Luis de la Pompa, Marcos Siguero-Álvarez, Sergio Callejas, Carlos Torroja, Ana Dopazo, Jorge de la Barrera, Donal MacGrogan y Manuel José Gómez.
    Research
    7 Nov 2022
    Circulation: Specific modifier genes determine the effect of mutations that cause non-compaction cardiomyopathy

    A CNIC study reveals that mutations previously identified in the gene MINDBOMB1 (MIB1) as causing non-compaction cardiomyopathy either provoke this disease or valve defects, depending on their combination with mutations in modifier genes

    Research
    3 Nov 2022
    Nature Cardiovascular Research: CNIC scientists identify the cause of arrhythmias and sudden death in Andersen-Tawil syndrome type 1

    CNIC scientists have identified a molecular mechanism that accounts for the arrhythmias, skeletal muscle weakness, and periodic paralysis in patients with this rare disease

    Descubren un factor clave que protege el corazón tras un infarto
    About the CNIC
    2 Nov 2022
    JCI: CNIC scientists identify a factor that protects the heart against damage after a heart attack

    A new study defines a mechanism that regulates inflammation after a myocardial infarction, opening a path to the use of the receptor

    Los complejos I, III, y IV de la cadena de transporte electrónico mitocondrial se asocian formando grandes estructuras llamadas supercomplejos. SCAF1 determina la asociación entre complejos de la cadena de transporte mitocondrial.
    Research
    18 Oct 2022
    Nature Metabolism: European scientists discover how the body optimizes its respiratory capacity during exercise

    A study, published in Nature Metabolism, is the first to demonstrate the key role played by mitochondria in adapting metabolism to different energy demands in humans