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A study published in Nature Cell Biology confirms that caveolae are essential for the mechanical responses of tissues subject to large mechanical forces (such as muscle, heart, blood vessels, and fat), whereas larger membrane depressions (termed 'dolines') are important for the response to weak or medium-strength forces

The finding provides a basis for mitigating the loss of muscle regenerative capacity in elderly people and for improving muscle repair in young healthy people

CNIC scientists have identified a molecular mechanism that accounts for the arrhythmias, skeletal muscle weakness, and periodic paralysis in patients with this rare disease

A study, published in Nature Metabolism, is the first to demonstrate the key role played by mitochondria in adapting metabolism to different energy demands in humans

The project will examine long-term changes in plasma biomarkers of neuronal injury, neuroinflammation, and Alzheimer's disease in participants in the PESA-CNIC-SANTANDER study who have undergone imaging studies to map brain metabolism. The goal of the project is to determine how cardiovascular risk factors during midlife impact brain function

The 3D atlas has allowed the scientists to identify the beginning of left–right asymmetry in the heart

The research will provide insights into the development of potential treatments for neurological diseases and obesity, among other human conditions

Most biological processes require the import to the cell nucleus of key regulatory factors; one of the most important of these factors is the protein YAP