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    E.g., 23/11/2024
    E.g., 23/11/2024
    Fibroblasto embrionario murino Cav1KO (izquierda, sin caveolas) muestra un mayor reclutamiento de integrina beta 1 activa (magenta) en torno a bolitas recubiertas con fibronectina, en comparación con un fibroblasto embrionario murino Cav1WT (derecha, con caveolas).
    Research
    13 Dec 2022
    eLife:CNIC scientists identify the essential role of cell-surface "nanofolds" and "glue" in the mechanical response of cells

    A new study published in eLife shows that small cups or nanofolds on the cell membrane called caveolae, by limiting abrupt changes in membrane tension, regulate the number and activity of mechanical microsensors on the cell surface called integrins
    La figura muestra imágenes mediante resonancia magnética cardíaca (A y B) y tomografía computarizada (C y D) de un corazón en diástole (A y C) y sístole (B y D) para el cálculo de la función de ambos ventrículos. VD: Ventrículo derecho; VI: Ventrículo izquierdo.
    Research
    12 Dec 2022
    European Journal of Heart Failure: A promising drug treatment for patients with pulmonary hypertension associated with heart disease

    The results of the SPHERE-HF study are published in the European Journal of Heart Failure. SPHERE-HF is a multicenter academic clinical trial led by investigators at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) and Hospital Clínic de Barcelona
    Transverse heart sections from wild type mice (WT) and transgenic mice overexpressing beta-3 adrenergic receptor in cardiomyocytes (c-h3tg) after 3 months of aortic stenosis (transaortic constriction, TAC) or control (sham). Hypertrophy after TAC was less severe in the transgenic mice
    Research
    29 Nov 2022
    Basic Research in Cardiology: A new therapeutic target for the prevention of heart failure due to aortic stenosis

    The experimental study, led by researchers at the CNIC, shows that boosting the expression of this adrenalin receptor in heart cells improves mitochondrial function in the heart
    Alejandro Salguero-Jiménez, Joaquim Grego-Bessa, Giovanna Giovinazzo, Fátima Sánchez-Cabo, Belén Prados, José Luis de la Pompa, Marcos Siguero-Álvarez, Sergio Callejas, Carlos Torroja, Ana Dopazo, Jorge de la Barrera, Donal MacGrogan y Manuel José Gómez.
    Research
    7 Nov 2022
    Circulation: Specific modifier genes determine the effect of mutations that cause non-compaction cardiomyopathy

    A CNIC study reveals that mutations previously identified in the gene MINDBOMB1 (MIB1) as causing non-compaction cardiomyopathy either provoke this disease or valve defects, depending on their combination with mutations in modifier genes

    Research
    3 Nov 2022
    Nature Cardiovascular Research: CNIC scientists identify the cause of arrhythmias and sudden death in Andersen-Tawil syndrome type 1

    CNIC scientists have identified a molecular mechanism that accounts for the arrhythmias, skeletal muscle weakness, and periodic paralysis in patients with this rare disease

    Descubren un factor clave que protege el corazón tras un infarto
    About the CNIC
    2 Nov 2022
    JCI: CNIC scientists identify a factor that protects the heart against damage after a heart attack

    A new study defines a mechanism that regulates inflammation after a myocardial infarction, opening a path to the use of the receptor

    Imagen obtenida por microscopía confocal en la que se observa el borde de la cicatriz glial producida tras el infarto cerebral, lo cual dificulta la posterior regeneración de la zona. Este evento es atenuado en gran medida a través del tratamiento con metoprolol intravenoso pre-reperfusión.
    Research
    3 Oct 2022
    BJP: CNIC scientists identify a neuroprotective action of metoprolol after a stroke

    Metoprolol, an established drug in the cardiologists armory, protects the brain during a stroke and greatly reduces its consequences
    Pablo García Pavía and Luis Escobar
    Research
    12 Sep 2022
    JACC: Scientists at the CNIC and Hospital Puerta de Hierro develop a tool to determine if dilated cardiomyopathy has a genetic origin

    The findings, published in the Journal of the American College of Cardiology (JACC), will enable physicians to make appropriate treatment adjustments for patients with this disease
    Fernando de Frutos y el Dr. Pablo García Pavía.
    Research
    29 Aug 2022
    JACC: CNIC scientists describe key features of one of the most frequent forms of hereditary dilated cardiomyopathy

    The findings, published in the Journal of the American College of Cardiology (JACC), represent a first step towards the personalized treatment of patients with this disease
    Valentín Fuster
    Research
    26 Aug 2022
    NEJM: The polypill reduces cardiovascular mortality by 33% in patients treated after myocardial infarction

    The results of the SECURE trial, coordinated by CNIC were presented in a Hot Line session at the European Society of Cardiology meeting (ESC 2022) in Barcelona and published at the NEJM