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    E.g., 23/11/2024
    E.g., 23/11/2024
    De izda. a dcha.: Gema González, Estefanía Núñez, Sergio Callejas, Juan Carlos Silla, Enrique Lara-Pezzi, Valentín Fuster, Fátima Sánchez Cabo, José Javier Fuster, Ana Dopazo, Borja Ibáñez, Marta Cortés, Alberto Benguría y Antonio Quesada.
    Research
    21 Jun 2023
    European Heart Journal: Atherosclerosis accelerates aging

    A new CNIC study shows that low-grade systemic inflammation triggered by subcinical atherosclerosis accelerates epigenetic aging in otherwise healthy young individuals
    En primer plano: Emilio Camafeita, Rui Benedito y Macarena Fernández; detrás, de izda. a dcha., Ana Dopazo, Jesús Vázquez, Alberto Benguria, Mariya Lytvyn, Severin Muhleder, Sofía Sánchez, Lourdes García.
    Research
    29 May 2023
    Nature Cardiovascular Research: Scientists identify how some angiogenic drugs used to treat cancer and heart disease cause vascular disease

    The new study, published in Nature Cardiovascular Research, will help to select the most effective and safe way to modulate angiogenesis in ischemic tissues or in cancer
    Dr. García Pavía
    Research
    21 May 2023
    NEJM: A Spanish team presents the first pharmacological treatment able to improve cardiac function in stiff-heart syndrome

    The team led by Dr. Pablo García-Pavía, based at the CNIC and Hospital Puerta de Hierro, has published the first study of a drug able to remove amyloid deposits from the heart

    Dr. Fuster
    Research
    6 Mar 2023
    JACC: High-Dose Anticoagulation Can Reduce Intubations and Improve Survival for Hospitalized COVID-19 Patients

    A study could change management of patients who are not critically ill
    Miguel Galán, David Sancho, Stefanie K. Wculek, Annalaura Mastrangelo, Verónica Miguel ,Ignacio Heras-Murillo, Diego Mañanes, José Antonio Enríquez and Andrea Curtabbi.
    Research
    3 Feb 2023
    IMMUNITY: Scientists identify a new therapeutic target in macrophages for the treatment of obesity-related diseases

    The discovery, published in the journal Immunity, identifies a new therapeutic route for conditions associated with obesity and metabolic syndrome, including cardiovascular disease
    Análisis de muestras humanas y experimentos en animales demuestran que la presencia de mutaciones en el gen p53 en sangre aumenta el riesgo de desarrollar aterosclerosis, la principal causa de enfermedad cardiovascular.
    Research
    16 Jan 2023
    Nature Cardiovascular Research: The 'guardian of the genome' protects against cardiovascular disease

    A CNIC study extends the understanding of how acquired mutations in blood cells act as a new cardiovascular risk factor
    Cells use two mechanisms to detect force: one gradual and progressive mediated by newly identified large membrane depressions called dolines (left); the other abrupt, activated above a certain threshold, and mediated by minute membrane invaginations called caveolae (right).
    Research
    23 Dec 2022
    Nature Cell Biology: A CNIC study shows that cells possess 2 mechanisms to allow them to respond to different force ranges

    A study published in Nature Cell Biology confirms that caveolae are essential for the mechanical responses of tissues subject to large mechanical forces (such as muscle, heart, blood vessels, and fat), whereas larger membrane depressions (termed 'dolines') are important for the response to weak or medium-strength forces
    Las células senescentes (mostradas por luminiscencia) aparecieron en el hombro de ratón después de la lesión
    Research
    19 Dec 2022
    Nature: Researchers characterize rare, damaged cells that block the functions of their neighbour healthy cells and identify ways to neutralize them and improve tissue regeneration

    The finding provides a basis for mitigating the loss of muscle regenerative capacity in elderly people and for improving muscle repair in young healthy people
    Mercedes Ricote, María Piedad Menéndez-Gutiérrez, Jesús Porcuna, Ana Paredes, Vanessa Núñez e Irene Calero.
    Research
    15 Dec 2022
    Blood: RXR, the cell protein that keeps blood stem cells young and fit

    A CNIC team has shown that the  retinoid and unsaturated fatty acid sensor RXR is a key protein in the maintenance of a balanced production of the different types of blood cells
    Fibroblasto embrionario murino Cav1KO (izquierda, sin caveolas) muestra un mayor reclutamiento de integrina beta 1 activa (magenta) en torno a bolitas recubiertas con fibronectina, en comparación con un fibroblasto embrionario murino Cav1WT (derecha, con caveolas).
    Research
    13 Dec 2022
    eLife:CNIC scientists identify the essential role of cell-surface "nanofolds" and "glue" in the mechanical response of cells

    A new study published in eLife shows that small cups or nanofolds on the cell membrane called caveolae, by limiting abrupt changes in membrane tension, regulate the number and activity of mechanical microsensors on the cell surface called integrins