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    E.g., 22/07/2024
    E.g., 22/07/2024
    Carlos Torroja, Jacob F. Bentzon, Paula Nogales, Laura Carramolino, Vanessa Cumbicus, Daniel Morales, Ana Dopazo, Verónica Labrador y Alberto Benguria
    Research
    1 Feb 2024
    Nature Cardiovascular Research: New approach to the design of therapies that enhance the effect of cholesterol-lowering drugs

    A study published in Nature Cardiovascular Research reveals smooth muscle-derived cells as a new target for reducing the size of atherosclerotic plaque. The results open up new avenues for the design of treatments to enhance the beneficial effect of cholesterol-lowering drugs
    Catarina Tristão Pereira, Enrique Lara Pezzi, Raquel Toribio Fernández, Borja Ibáñez, Valentín Fuster, Sergio Callejas, Marta Cortés Canteli, Ana Dopazo, Pilar Martín, Inés García Lunar e Irene Fernández Nueda.
    Research
    23 Jan 2024
    Circulation Research: APOE genetic variants linked to Alzheimer disease are also associated with the development of subclinical aterosclerosis

    The most potent genetic risk factor for Alzheimer disease, APOE4, is associated with an elevated risk of developing subclinical atherosclerosis in middle age, whereas the Alzheimer-protective variant of the same gene, APOE2, protects against subclinical atherosclerosis
    Ayelén M. Santamans y Guadalupe Sabio
    Research
    19 Jan 2024
    Science Advances: First therapeutic target for preserving heart function in patients with pulmonary hypertension

    A team led by scientists from the CNIC and CNIO has identified a potential therapeutic target that protects the heart in patients with pulmonary hypertension
    Edward Pearce
    Research
    21 Dec 2023
    Edward Pearce: "Prevention is always more economical than treating a heart attack or a heart transplant"

    Johns Hopkins UniversityBloomberg School of Public HealthBaltimore
    Marcos Siguero Álvarez, Luis Luna Zurita, José Luis de la Pompa y Brenda Giselle Flores Garza
    Research
    11 Dec 2023
    Circulation Research: CNIC scientists identify the molecular mechanisms controlling the genes involved in proper formation of the heart valves

    The findings, published in the journal Circulation Research, not only highlight the gene regulatory mechanisms that control valve formation, but also offer clues for future medical advances
    Foto de grupo Jacardi
    About the CNIC
    29 Nov 2023
    CNIC and the i+12 Institute participate in the most ambitious EU project to reduce the burden of cardiovascular diseases and diabetes

    CNIC and the i+12 Institute co-lead one of the working groups of this initiative.
    Imágenes de mapeado óptico de dos corazones distintos de ratones que desarrollaron fibrilación ventricular.
    Research
    27 Nov 2023
    Nature Cardiovascular Research: Spanish scientists discover a promising therapeutic target for cardiac arrhythmias
    Representative results from participants showing atherosclerosis progression (left) and regression (disappearance of plaques, right) in arteries of the neck (carotids) and groin (femorals). Each image pair shows the results of the initial study at baseline and the follow-up study of the same artery 6 years later. The images show representative vascular ultrasound images on the right and 3-dimensional reconstructions on the left.
    Research
    20 Nov 2023
    JACC: Younger people are more vulnerable to the effects of cardiovascular risk associated with high blood cholesterol and hypertension

    Atherosclerosis, previously believed to be an irreversible progressive disease, can be reversed if risk factors are contolled early enough
    About the CNIC
    17 Nov 2023
    Dr. Francisco Sánchez-Madrid awarded the 2023 Robert Koch Prize

    This work is of fundamental importance for understanding the immune system and its reactions
    Neuregulin-1 induces changes in actin filaments during ventricular maturation. Actinin staining of a mouse embryo heart reveals a striated actin pattern corresponding to mature trabecular sarcomeres (green). The magnified view shows the differences in luminosity that distinguish the more organized actin filaments of the trabecular myocardium from the less organized compact layer
    Research
    10 Nov 2023
    CIRCULATION RESEARCH: CNIC scientists identify the crucial role of the protein neuregulin-1 in heart development

    Neuregulin-1 (Nrg1) plays an essential role in the transformation of the heart from its delicate primordial structure into the powerful beating mature organ