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E.g., 30/11/2024
E.g., 30/11/2024
Dr. García Pavía
Research
21 May 2023

The team led by Dr. Pablo García-Pavía, based at the CNIC and Hospital Puerta de Hierro, has published the first study of a drug able to remove amyloid deposits from the heart

Dr. Fuster
Research
6 Mar 2023

A study could change management of patients who are not critically ill

Imágenes del corazón obtenidas mediante resonancia magnética en las que se analizan distintas estructuras de la anatomía y función del corazón: aurículas (paneles A y B), ventrículos (paneles C y D), características del tejido cardiaco (paneles E y F).
Research
3 Mar 2023

The results, published in eClinicalMedicine, have direct implications for clinical practice by providing a list of reference values for a multitude of cardiac parameters used in daily practice

Miguel Galán, David Sancho, Stefanie K. Wculek, Annalaura Mastrangelo, Verónica Miguel ,Ignacio Heras-Murillo, Diego Mañanes, José Antonio Enríquez and Andrea Curtabbi.
Research
3 Feb 2023

The discovery, published in the journal Immunity, identifies a new therapeutic route for conditions associated with obesity and metabolic syndrome, including cardiovascular disease

Análisis de muestras humanas y experimentos en animales demuestran que la presencia de mutaciones en el gen p53 en sangre aumenta el riesgo de desarrollar aterosclerosis, la principal causa de enfermedad cardiovascular.
Research
16 Jan 2023

A CNIC study extends the understanding of how acquired mutations in blood cells act as a new cardiovascular risk factor

Cells use two mechanisms to detect force: one gradual and progressive mediated by newly identified large membrane depressions called dolines (left); the other abrupt, activated above a certain threshold, and mediated by minute membrane invaginations called caveolae (right).
Research
23 Dec 2022

A study published in Nature Cell Biology confirms that caveolae are essential for the mechanical responses of tissues subject to large mechanical forces (such as muscle, heart, blood vessels, and fat), whereas larger membrane depressions (termed 'dolines') are important for the response to weak or medium-strength forces

Las células senescentes (mostradas por luminiscencia) aparecieron en el hombro de ratón después de la lesión
Research
19 Dec 2022

The finding provides a basis for mitigating the loss of muscle regenerative capacity in elderly people and for improving muscle repair in young healthy people

Fibroblasto embrionario murino Cav1KO (izquierda, sin caveolas) muestra un mayor reclutamiento de integrina beta 1 activa (magenta) en torno a bolitas recubiertas con fibronectina, en comparación con un fibroblasto embrionario murino Cav1WT (derecha, con caveolas).
Research
13 Dec 2022

A new study published in eLife shows that small cups or nanofolds on the cell membrane called caveolae, by limiting abrupt changes in membrane tension, regulate the number and activity of mechanical microsensors on the cell surface called integrins

La figura muestra imágenes mediante resonancia magnética cardíaca (A y B) y tomografía computarizada (C y D) de un corazón en diástole (A y C) y sístole (B y D) para el cálculo de la función de ambos ventrículos. VD: Ventrículo derecho; VI: Ventrículo izquierdo.
Research
12 Dec 2022

The results of the SPHERE-HF study are published in the European Journal of Heart Failure. SPHERE-HF is a multicenter academic clinical trial led by investigators at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) and Hospital Clínic de Barcelona

Alejandro Salguero-Jiménez, Joaquim Grego-Bessa, Giovanna Giovinazzo, Fátima Sánchez-Cabo, Belén Prados, José Luis de la Pompa, Marcos Siguero-Álvarez, Sergio Callejas, Carlos Torroja, Ana Dopazo, Jorge de la Barrera, Donal MacGrogan y Manuel José Gómez.
Research
7 Nov 2022

A CNIC study reveals that mutations previously identified in the gene MINDBOMB1 (MIB1) as causing non-compaction cardiomyopathy either provoke this disease or valve defects, depending on their combination with mutations in modifier genes