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    E.g., 25/11/2024
    E.g., 25/11/2024
    Experimental design of the study and summary of the results obtained
    Research
    21 Apr 2020
    JACC: Spanish scientists identify a biomarker that detects atherosclerosis before the appearance of symptoms

    The study, published today in JACC, shows that activation of the complement system is one of the most characteristic molecular changes taking place in the early stages of the development of atherosclerotic plaques
    En la imagen se muestra con un asterisco la presencia de una placa de aterosclerosis avanzada en la carótida común detectada por la técnica de ecografía 3D que no llega a ocasionar una obstrucción significativa de la luz del vaso (es <50%). Se puede comprobar con precisión su extensión en las 3 dimensiones del espacio lo que nos permite detectar cambios en su volumen para determinar si existe un avance de la enfermedad.
    Research
    7 Apr 2020
    JACC: Atherosclerosis progresses rapidly in healthy people from the age of 40

    A CNIC study published in JACC demonstrates that atheroma plaques extend rapidly in the arteries of asymptomatic individuals aged between 40 and 50 years participating in the PESA-CNIC-Santander study.
    Microscopía confocal mostrando un macrófago peritoneal de un ratón deficiente en RXR, donde se observa un alto contenido de lípidos (verde) dentro de vesículas ácidas (rojo).
    Research
    3 Apr 2020
    Nature Communications: CNIC scientists discover a new molecular mechanism that regulates the sentinel cells of the immune system

    Published in Nature Communications, the study suggests that it may be possible to regulate the number and activity of these macrophages with drugs that modulate the nuclear receptor RXR
    De izquierda a derecha José Manuel Alfonso Almazán, Jorge García Quintanilla, Manuel Marina Breysse, José María Lillo Castellano, Julián Pérez Villacastín, David Filgueiras Rama, José Jalife y Nicasio Pérez Castellano.
    Research
    16 Dec 2019
    Europace: Personalized medicine for atrial fibrillation

    The study, published in Europace, uses signals from implantable devices—pacemakers and defibrillators—to analyze electrical signals in the heart during episodes of atrial fibrillation
    SRSF3 expression in adult cardiomyocytes. Pink staining shows SRSF3 expression in cell nuclei, which are stained blue. Green staining shows the presence of troponin, a sarcomere protein expressed in cardiomyocytes.
    Research
    4 Jul 2019
    Circulation Research: CNIC scientists identify an essential protein for correct heart contraction and survival

    A new study published in Circulation Research shows that loss of cardiac expression of SRSF3 leads to a critical reduction in the expression of genes related to contraction
    About the CNIC
    12 Jun 2019
    Dr. Miguel Torres elected a member of the European Molecular Biology Organization – EMBO

    EMBO promotes excellence in scientific research, and one of its major goals is to support talented researchers at all stages of their careers
    Valentín Fuster
    Research
    23 Apr 2019
    JACC: Early Intervention in preschool is a unique opportunity for promoting a healthy lifestyle

    New study proves educating young children on health and fitness is effective
    Dr. José María Mendiguren, Director de Servicios Médicos de Banco Santander, Leticia Fernández-Friera, cardióloga del CNIC y del Hospital Universitario HM Montepríncipe, y Dr. Valentín Fuster, Director del CNIC.
    Research
    26 Mar 2019
    JACC: Advanced imaging technology predicts cardiovascular risk from inflammation detected in arteries

    The results, published in JACC, demonstrate the potential of this technology to generate images of the inflammation associated with systemic atherosclerosis; this information will be useful for the study of early stages of this disease and will help to identify individuals who will benefit from early medical intervention
    Pilar Gonzalo, Rosa Nevado, Ricardo Villa-Bellosta, Magda R. Hamczyk, María J. Andrés-Manzano, and Vicente Andrés.
    Research
    12 Mar 2019
    EMBO Molecular Medicine: CNIC scientists discover a new therapeutic target for blocking early atherosclerosis in progeria

    This new results, published in EMBO Molecular Medicine, identify a possible therapeutic target for this genetic disease
    Annalaura Mastrangelo, David Sancho, Salvado Iborra, María Martínez-López y Ruth Conde Garrosa.
    Research
    30 Jan 2019
    Immunity: Scientists identify a new "watchdog" that controls intestinal bacteria

    The study, published in Immunity, shows that some intestinal bacteria, such as Lactobacillus, strengthen the intestinal barrier by interacting with an immune cell receptor called Mincle (Clec4e)