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    E.g., 03/04/2025
    E.g., 03/04/2025
    Fibroblasto embrionario murino Cav1KO (izquierda, sin caveolas) muestra un mayor reclutamiento de integrina beta 1 activa (magenta) en torno a bolitas recubiertas con fibronectina, en comparación con un fibroblasto embrionario murino Cav1WT (derecha, con caveolas).
    Research
    13 Dec 2022
    eLife:CNIC scientists identify the essential role of cell-surface "nanofolds" and "glue" in the mechanical response of cells

    A new study published in eLife shows that small cups or nanofolds on the cell membrane called caveolae, by limiting abrupt changes in membrane tension, regulate the number and activity of mechanical microsensors on the cell surface called integrins
    La figura muestra imágenes mediante resonancia magnética cardíaca (A y B) y tomografía computarizada (C y D) de un corazón en diástole (A y C) y sístole (B y D) para el cálculo de la función de ambos ventrículos. VD: Ventrículo derecho; VI: Ventrículo izquierdo.
    Research
    12 Dec 2022
    European Journal of Heart Failure: A promising drug treatment for patients with pulmonary hypertension associated with heart disease

    The results of the SPHERE-HF study are published in the European Journal of Heart Failure. SPHERE-HF is a multicenter academic clinical trial led by investigators at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) and Hospital Clínic de Barcelona
    Los complejos I, III, y IV de la cadena de transporte electrónico mitocondrial se asocian formando grandes estructuras llamadas supercomplejos. SCAF1 determina la asociación entre complejos de la cadena de transporte mitocondrial.
    Research
    18 Oct 2022
    Nature Metabolism: European scientists discover how the body optimizes its respiratory capacity during exercise

    A study, published in Nature Metabolism, is the first to demonstrate the key role played by mitochondria in adapting metabolism to different energy demands in humans

    Imagen obtenida por microscopía confocal en la que se observa el borde de la cicatriz glial producida tras el infarto cerebral, lo cual dificulta la posterior regeneración de la zona. Este evento es atenuado en gran medida a través del tratamiento con metoprolol intravenoso pre-reperfusión.
    Research
    3 Oct 2022
    BJP: CNIC scientists identify a neuroprotective action of metoprolol after a stroke

    Metoprolol, an established drug in the cardiologists armory, protects the brain during a stroke and greatly reduces its consequences
    Pablo García Pavía and Luis Escobar
    Research
    12 Sep 2022
    JACC: Scientists at the CNIC and Hospital Puerta de Hierro develop a tool to determine if dilated cardiomyopathy has a genetic origin

    The findings, published in the Journal of the American College of Cardiology (JACC), will enable physicians to make appropriate treatment adjustments for patients with this disease
    Los adolescentes que duermen menos de 8 horas tienen más probabilidades de tener sobrepeso u obesidad
    Research
    29 Aug 2022
    Insufficient sleep in teenagers is associated with overweight and obesity

    Excess weight and metabolic syndrome are associated with cardiovascular disease, suggesting that health promotion programs in schools should teach good sleep habits
    Fernando de Frutos y el Dr. Pablo García Pavía.
    Research
    29 Aug 2022
    JACC: CNIC scientists describe key features of one of the most frequent forms of hereditary dilated cardiomyopathy

    The findings, published in the Journal of the American College of Cardiology (JACC), represent a first step towards the personalized treatment of patients with this disease
    Valentín Fuster
    Research
    26 Aug 2022
    NEJM: The polypill reduces cardiovascular mortality by 33% in patients treated after myocardial infarction

    The results of the SECURE trial, coordinated by CNIC were presented in a Hot Line session at the European Society of Cardiology meeting (ESC 2022) in Barcelona and published at the NEJM

    Imagen de histología que muestra la comparación del tamaño del corazón de un ratón normal (izquierda) y un ratón deficiente para la proteína MKK6 (derecha).
    Research
    9 Aug 2022
    eLife: CNIC scientists uncover opposing roles of p38 proteins in cardiac hypertrophy

    A new study published in eLife shows that inhibition of p38γ/δ is a potential therapeutic strategy for the treatment of hypertrophic cardiomyopathy, but that this strategy has yet to be explored because of the lack of specific inhibitors for these p38 family members
    Juan Domingo Gisbert
    About the CNIC
    24 Jun 2022
    Juan Domingo Gisbert: "Combining CNIC and BBRC data will allow us to answer questions of great relevance for the prevention of Alzheimer's in healthy subjects"

    Juan Domingo Gispert López, head of the Barcelonaβeta Brain Research Center and CNIC (Spanish National Centre for Cardiovascular Research) researcher