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    E.g., 28/11/2024
    E.g., 28/11/2024
    Experimental design of the study and summary of the results obtained
    Research
    21 Apr 2020
    JACC: Spanish scientists identify a biomarker that detects atherosclerosis before the appearance of symptoms

    The study, published today in JACC, shows that activation of the complement system is one of the most characteristic molecular changes taking place in the early stages of the development of atherosclerotic plaques
    En la imagen se muestra con un asterisco la presencia de una placa de aterosclerosis avanzada en la carótida común detectada por la técnica de ecografía 3D que no llega a ocasionar una obstrucción significativa de la luz del vaso (es <50%). Se puede comprobar con precisión su extensión en las 3 dimensiones del espacio lo que nos permite detectar cambios en su volumen para determinar si existe un avance de la enfermedad.
    Research
    7 Apr 2020
    JACC: Atherosclerosis progresses rapidly in healthy people from the age of 40

    A CNIC study published in JACC demonstrates that atheroma plaques extend rapidly in the arteries of asymptomatic individuals aged between 40 and 50 years participating in the PESA-CNIC-Santander study.
    Microscopía confocal mostrando un macrófago peritoneal de un ratón deficiente en RXR, donde se observa un alto contenido de lípidos (verde) dentro de vesículas ácidas (rojo).
    Research
    3 Apr 2020
    Nature Communications: CNIC scientists discover a new molecular mechanism that regulates the sentinel cells of the immune system

    Published in Nature Communications, the study suggests that it may be possible to regulate the number and activity of these macrophages with drugs that modulate the nuclear receptor RXR
    Imágenes de las coroides de ratones control (izquierda) y tras la eliminación de IHH de las células endoteliales (derecha), lo que resulta en una disminución del número de mastocitos (puntos blancos).
    Research
    20 Mar 2020
    Journal of Experimental Medicine:CNIC scientists identify an immunological regulatory circuit that may play a central role in ocular diseases

    Scientists at the CNIC and Weill Cornell Medicine have identified an inflammatory regulatory circuit controlled by a subtype of endothelial cells in the eye
    Dr. Filip Swirski
    About the CNIC
    28 Feb 2020
    "Sleep has been proven to be a risk factor for cardiovascular disease”

    Dr. Filip Swirski is associate professor at Harvard Medical School and Massachusetts General Hospital (USA) and one of the leading experts on the relationship between sleep and heart disease
    María Ángeles Moro
    About the CNIC
    11 Feb 2020
    "Various diseases and all very mechanistically different, are included under the name of vascular dementia, or better called, cognitive vascular deterioration"

    María Ángeles Moro leads the CNIC's Neurovascular Pathophysiology Laboratory.
    About the CNIC
    29 Jan 2020
    CNIC is one of 4 finalists competing for €35m funding from the British Heart Foundation

    Dr. Valentín Fuster’s group will contribute to the iMAP project through the PESA-CNIC-Santander study
    Andrés Hidalgo, Jose María Adrover y Alejandra Aroca
    Research
    14 Jan 2020
    Nature Immunology: Neutrophils are equipped with a 'disarmament' program that prevents the immune system going 'out of control'

    The newly identified immune control system is located within one of the most important cell types of the immune system, the neutrophil
    Se muestra el corazón y tejidos anejos con la visualización de los vasos linfáticos y las células descendientes del segundo campo cardíaco en rojo.
    Research
    10 Jan 2020
    Development Cell: An international study discovers a new origin of lymphatic vessels in the heart

    The international team led by CNIC researchers Drs Miguel Torres and Ghislaine Lioux found that the cardiac lymphatic vasculature does not have a single origin, but is instead formed by cells originating in a variety of tissues

    De izda. a dcha.: Asier Echarri, Miguel Ángel del Pozo, Diana Velázquez, Carla Huerta, Sara Sánchez, María García, Raffaele Strippoli, Enrique Calvo, Jorge Alegre-Cebollada.
    Research
    20 Dec 2019
    Nature Communications: The 'airbag' that protects cells against stress

    CNIC scientists have identified the molecular mechanisms that allow our cells to adapt to, protect themselves against, and survive mechanical stress