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E.g., 24/11/2024
E.g., 24/11/2024
Miguel Ángel del Pozo, Jorge Alegre-Cebollada, Carla Huerta-López, Alejandro Clemente-Manteca, Diana Velázquez-Carreras, and Elías Herrero-Galán.
Research
15 Nov 2024

A study by CNIC, published in Science Advances, offers a new approach to understanding how cells respond to mechanical signals from their environment, redefining the comprehension of the relationship between cells and their physical surroundings.

María J. Andrés-Manzano, Pilar Gonzalo, Rosa M. Carmona, Cristina González-Gómez, Ana Barettino, Ignacio Benedicto, Vicente Andrés and Ana Dopazo.
Research
7 Oct 2024

A team of scientists from the CNIC and the CSIC has identified a key mechanism in the development of atherosclerosis in patients with the rare genetic disease Hutchinson-Gilford progeria syndrome

Jesús Vázquez Cobos, Iván López-Montero, Enrique Calvo Alcocer, Pablo Hernansanz Agustín, Carmen Morales Vidal, José Antonio Enríquez, Rebeca Acín Pérez, Sara Jaroszewicz y José Luis Cabrera Alarcón.
Research
19 Sep 2024

The study, published in Cell, reveals an essential function of sodium transport in cellular energy generation

 Dr. Fuster
De izquierda a derecha: Immunofluorescencia en sección de corazón de pez cebra tras criolesion mostrando células proliferativas (blanco), cardiomiocitos (rojo) núcleos celulares (azul). Imagen de Microscopia electrónica mostrando mitocondrias. Gel Blue Native mostrando bandas correspondientes a supercomplejos formados por CIII (rojo) y CIV (verde).
Research
6 May 2024

Scientists at the CNIC, CIBER, and University of Berne identify the fundamental role of a family of proteins in an essential process for cellular energy production

María Jesús Andrés, Carla Espinós (detrás), Rosa M Nevado (delante, al lado de MJA), Miguel de la Fuente, Rosa Carmona, Ana Barettino, Vicente Andrés, Pilar Gonzalo e Ignacio Benedicto.
Research
19 Apr 2024

The elimination of progerin from vascular smooth muscle cells, but not from endothelial cells, prevents the atherosclerosis associated with Hutchinson-Gilford progeria syndrome (HGPS)

Carlos Torroja, Jacob F. Bentzon, Paula Nogales, Laura Carramolino, Vanessa Cumbicus, Daniel Morales, Ana Dopazo, Verónica Labrador y Alberto Benguria
Research
1 Feb 2024

A study published in Nature Cardiovascular Research reveals smooth muscle-derived cells as a new target for reducing the size of atherosclerotic plaque. The results open up new avenues for the design of treatments to enhance the beneficial effect of cholesterol-lowering drugs


Catarina Tristão Pereira, Enrique Lara Pezzi, Raquel Toribio Fernández, Borja Ibáñez, Valentín Fuster, Sergio Callejas, Marta Cortés Canteli, Ana Dopazo, Pilar Martín, Inés García Lunar e Irene Fernández Nueda.
Research
23 Jan 2024

The most potent genetic risk factor for Alzheimer disease, APOE4, is associated with an elevated risk of developing subclinical atherosclerosis in middle age, whereas the Alzheimer-protective variant of the same gene, APOE2, protects against subclinical atherosclerosis

Neuregulin-1 induces changes in actin filaments during ventricular maturation. Actinin staining of a mouse embryo heart reveals a striated actin pattern corresponding to mature trabecular sarcomeres (green). The magnified view shows the differences in luminosity that distinguish the more organized actin filaments of the trabecular myocardium from the less organized compact layer
Research
10 Nov 2023

Neuregulin-1 (Nrg1) plays an essential role in the transformation of the heart from its delicate primordial structure into the powerful beating mature organ