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E.g., 22/11/2024
De izquierda a derecha: Cristina Sanchez-Ramos, Nieves Garcia-Quintans, David Morera, Mariya Lytvyn, Juan A Bernal, Mª Ángeles Sanguino, Daniel Martín Perez, Fernando de Benito, David Sanz y Emilio Camafeita
Research
23 Oct 2023

This disease, which can trigger sudden death in elite athletes, is caused by genetic mutations that affect proteins responsible for connecting and coordinating the muscle cells (myocytes) in the myocardium the heart’s muscular wall

la Dra. Mercedes Ricote y la Dra. Ana Paredes
About the CNIC
29 Sep 2023

The Spanish National Centre for Cardiovascular Research (CNIC) researcher Dr Ana Paredes has won the International Birnstiel Award 2023


The image represent glucose uptake in the brain measured by positron emission tomography in middle-aged individuals with low (top) or high (bottom) sustained cardiovascular risk over 5 years. The colors represent cerebral glucose consumption, with red indicating higher consumption and blue lower consumption
Research
31 Aug 2023

A study published in The Lancet Healthy Longevity shows that brain metabolism, detected with advanced imaging techniques, declines more sharply in middle-aged people with a sustained high cardiovascular risk over 5 years

Alejo Rodríguez-Fraticelli
Análisis de muestras humanas y experimentos en animales demuestran que la presencia de mutaciones en el gen p53 en sangre aumenta el riesgo de desarrollar aterosclerosis, la principal causa de enfermedad cardiovascular.
Research
16 Jan 2023

A CNIC study extends the understanding of how acquired mutations in blood cells act as a new cardiovascular risk factor

Cells use two mechanisms to detect force: one gradual and progressive mediated by newly identified large membrane depressions called dolines (left); the other abrupt, activated above a certain threshold, and mediated by minute membrane invaginations called caveolae (right).
Research
23 Dec 2022

A study published in Nature Cell Biology confirms that caveolae are essential for the mechanical responses of tissues subject to large mechanical forces (such as muscle, heart, blood vessels, and fat), whereas larger membrane depressions (termed 'dolines') are important for the response to weak or medium-strength forces

Las células senescentes (mostradas por luminiscencia) aparecieron en el hombro de ratón después de la lesión
Research
19 Dec 2022

The finding provides a basis for mitigating the loss of muscle regenerative capacity in elderly people and for improving muscle repair in young healthy people

Mercedes Ricote, María Piedad Menéndez-Gutiérrez,  Jesús Porcuna,  Ana Paredes, Vanessa Núñez e Irene Calero.
Research
15 Dec 2022

A CNIC team has shown that the  retinoid and unsaturated fatty acid sensor RXR is a key protein in the maintenance of a balanced production of the different types of blood cells

Fibroblasto embrionario murino Cav1KO (izquierda, sin caveolas) muestra un mayor reclutamiento de integrina beta 1 activa (magenta) en torno a bolitas recubiertas con fibronectina, en comparación con un fibroblasto embrionario murino Cav1WT (derecha, con caveolas).
Research
13 Dec 2022

A new study published in eLife shows that small cups or nanofolds on the cell membrane called caveolae, by limiting abrupt changes in membrane tension, regulate the number and activity of mechanical microsensors on the cell surface called integrins