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The study, published in Nature in 2019, revealed relevant data about the involvement of the protein p38gamma in the development of the main type of primary liver cancer, which affects over a million people a year worldwide

Scientists at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) have designed a new strategy to potentiate immunotherapy, the treatment that has revolutionized cancer management

The project will investigate the role of clonal hematopoiesis—the formation of mutated hematopoietic stem-cell clones promoted by anti-cancer therapies—in the development of atherosclerosis and associated cardiovascular disease

CNIC scientists have designed an animal model to study the development of liver cancer caused by bile acids

Published in Nature Communications, the study suggests that it may be possible to regulate the number and activity of these macrophages with drugs that modulate the nuclear receptor RXR

CNIC scientists have shown for the first time that a protein related to cell stress also regulates cell division

• Adiponectin, secreted by adipose tissue, protects against the development of the main form of liver cancer
• Women produce the hormone in larger quantities than men, and adiponectin release also declines in people with obesity
• The results open the route to combating a cancer for which there is currently no treatment and that is the fourth cause of death in the world.

The results have implications for patient prognosis, since detection of this marker can prompt intervention to prevent irreversible damage