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CNIC scientists have designed an animal model to study the development of liver cancer caused by bile acids

Published in Nature Communications, the study suggests that it may be possible to regulate the number and activity of these macrophages with drugs that modulate the nuclear receptor RXR

CNIC scientists have shown for the first time that a protein related to cell stress also regulates cell division

• Adiponectin, secreted by adipose tissue, protects against the development of the main form of liver cancer
• Women produce the hormone in larger quantities than men, and adiponectin release also declines in people with obesity
• The results open the route to combating a cancer for which there is currently no treatment and that is the fourth cause of death in the world.

The results have implications for patient prognosis, since detection of this marker can prompt intervention to prevent irreversible damage

Dr. Sabio leads a research group at the Carlos III National Cardiovascular Research Center (CNIC) whose main line of research are diseases related to obesity, like cardiovascular diseases, diabetes and liver cancer.

The study, published in Nature Communications, demonstrates that tissue-resident and circulating memory T cells cooperate in anti-tumor immunity

Every year 400000 people are diagnosed with lymphoma, and 200000 people die from the consequences of this blood cancer