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CNIC researchers, led by Dr. José Jalife, have made a key discovery about cardiac arrhythmias in Andersen-Tawil syndrome (ATS)

The most potent genetic risk factor for Alzheimer disease, APOE4, is associated with an elevated risk of developing subclinical atherosclerosis in middle age, whereas the Alzheimer-protective variant of the same gene, APOE2, protects against subclinical atherosclerosis

The findings, published in the journal Circulation Research, not only highlight the gene regulatory mechanisms that control valve formation, but also offer clues for future medical advances

Neuregulin-1 (Nrg1) plays an essential role in the transformation of the heart from its delicate primordial structure into the powerful beating mature organ 

A CNIC study reveals that mutations previously identified in the gene MINDBOMB1 (MIB1) as causing non-compaction cardiomyopathy either provoke this disease or valve defects, depending on their combination with mutations in modifier genes

The mixing of mitochondrial DNAs (mtDNAs) of two distinct origins can have damaging medium- and long-term effects, according to the results of a new study published in Circulation

Scientists from the CNIC and the CIBERCV have generated the first experimental animal model that develops Hutchinson-Gilford Progeria Syndrome and allows its controlled reversal

The new findings, published in Circulation Research, could spur the development of new tools for the treatment of cardiac hypertrophy